eprintid: 5020 rev_number: 13 eprint_status: archive userid: 2 dir: disk0/00/00/50/20 datestamp: 2022-12-12 23:30:11 lastmod: 2023-07-17 23:30:39 status_changed: 2022-12-12 23:30:11 type: article metadata_visibility: show creators_name: Nacka-Aleksić, Mirjana creators_name: Pirković, Andrea creators_name: Vilotić, Aleksandra creators_name: Bojić-Trbojević, Žanka creators_name: Jovanović Krivokuća, Milica creators_name: Giampieri, Francesca creators_name: Battino, Maurizio creators_name: Dekanski, Dragana creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: francesca.giampieri@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es creators_id: title: The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: polyphenols; early pregnancy; trophoblast; gestational diabetes mellitus; preeclampsia abstract: Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring. date: 2022-12 publication: Nutrients volume: 14 number: 24 pagerange: 5246 id_number: doi:10.3390/nu14245246 refereed: TRUE issn: 2072-6643 official_url: http://doi.org/10.3390/nu14245246 access: open language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring. metadata Nacka-Aleksić, Mirjana; Pirković, Andrea; Vilotić, Aleksandra; Bojić-Trbojević, Žanka; Jovanović Krivokuća, Milica; Giampieri, Francesca; Battino, Maurizio y Dekanski, Dragana mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR (2022) The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders. Nutrients, 14 (24). p. 5246. ISSN 2072-6643 document_url: http://repositorio.uneatlantico.es/id/eprint/5020/1/nutrients-14-05246-with-cover.pdf