eprintid: 4009 rev_number: 12 eprint_status: archive userid: 2 dir: disk0/00/00/40/09 datestamp: 2022-10-17 23:30:06 lastmod: 2023-07-11 23:30:49 status_changed: 2022-10-17 23:30:06 type: article metadata_visibility: show creators_name: Navarro-Hortal, María D. creators_name: Romero-Márquez, Jose M. creators_name: Muñoz-Ollero, Pedro creators_name: Jiménez-Trigo, Victoria creators_name: Esteban-Muñoz, Adelaida creators_name: Tutusaus, Kilian creators_name: Giampieri, Francesca creators_name: Battino, Maurizio creators_name: Sánchez-González, Cristina creators_name: Rivas-García, Lorenzo creators_name: Llopis, Juan creators_name: Forbes-Hernández, Tamara Y. creators_name: Quiles, José L. creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: kilian.tutusaus@uneatlantico.es creators_id: francesca.giampieri@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es creators_id: creators_id: creators_id: creators_id: creators_id: jose.quiles@uneatlantico.es title: Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honey via HSP-16.2 and SKN-1/Nrf2 pathways in an in vivo model of Alzheimer's disease ispublished: pub subjects: uneat_bm subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica full_text_status: public abstract: Alzheimer's is a chronic degenerative disease of the central nervous system considered the leading cause of dementia in the world. It is characterized by two etiopathological events related to oxidative stress: the aggregation of β-amyloid peptide and the formation of neurofibrillary tangles of hyperphosphorylated Tau protein in the brain. The incidence of this disease increases with age and has been associated with inadequate lifestyles. Some natural compounds have been shown to improve the hallmarks of the disease. However, despite its potential, there is no scientific evidence about Manuka honey (MH) in this regard. In the present work we evaluated the effect of MH on the toxicity induced by Aβ aggregation and Tau in a Caenorhabditis elegans model. Our results demonstrated that MH was able to improve indicators of oxidative stress and delayed Aβ-induced paralysis in the AD model CL4176 through HSP-16.2 and SKN-1/NRF2 pathways. Nevertheless, its sugar content impaired the indicators of locomotion (an indicator of tau neurotoxicity) in both the transgenic strain BR5706 and in the wild-type N2 worms. date: 2022-10 publication: Food & Function id_number: doi:10.1039/D2FO01739C refereed: TRUE issn: 2042-6496 official_url: http://doi.org/10.1039/D2FO01739C access: open language: en citation: Artículo Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Abierto Inglés Alzheimer's is a chronic degenerative disease of the central nervous system considered the leading cause of dementia in the world. It is characterized by two etiopathological events related to oxidative stress: the aggregation of β-amyloid peptide and the formation of neurofibrillary tangles of hyperphosphorylated Tau protein in the brain. The incidence of this disease increases with age and has been associated with inadequate lifestyles. Some natural compounds have been shown to improve the hallmarks of the disease. However, despite its potential, there is no scientific evidence about Manuka honey (MH) in this regard. In the present work we evaluated the effect of MH on the toxicity induced by Aβ aggregation and Tau in a Caenorhabditis elegans model. Our results demonstrated that MH was able to improve indicators of oxidative stress and delayed Aβ-induced paralysis in the AD model CL4176 through HSP-16.2 and SKN-1/NRF2 pathways. Nevertheless, its sugar content impaired the indicators of locomotion (an indicator of tau neurotoxicity) in both the transgenic strain BR5706 and in the wild-type N2 worms. metadata Navarro-Hortal, María D.; Romero-Márquez, Jose M.; Muñoz-Ollero, Pedro; Jiménez-Trigo, Victoria; Esteban-Muñoz, Adelaida; Tutusaus, Kilian; Giampieri, Francesca; Battino, Maurizio; Sánchez-González, Cristina; Rivas-García, Lorenzo; Llopis, Juan; Forbes-Hernández, Tamara Y. y Quiles, José L. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, kilian.tutusaus@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.quiles@uneatlantico.es (2022) Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honey via HSP-16.2 and SKN-1/Nrf2 pathways in an in vivo model of Alzheimer's disease. Food & Function. ISSN 2042-6496 document_url: http://repositorio.uneatlantico.es/id/eprint/4009/1/d2fo01739c%20%281%29.pdf