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primary topic: Valorization of Purple Prickly Pear Peel By‐Products: Antiproliferative and Pro‐Apoptotic Effects on Human Colorectal Cancer Cells HCT116

Valorization of Purple Prickly Pear Peel By‐Products: Antiproliferative and Pro‐Apoptotic Effects on Human Colorectal Cancer Cells HCT116
type: AcademicArticle
type: Article
abstract: Opuntia ficus-indica peel is known to possess antioxidant, anti-inflammatory, and anticancer activities and currently is discarded or used for animal feeding. Within this context, the aim of this work was to evaluate the antiproliferative and pro-apoptotic effect of purple prickly pear peel extract (PPE) on the human colon adenocarcinoma cancer cell line (HTC116). The methanolic extract of PPE was characterized in terms of betalain and polyphenols as well as total antioxidant capacity. Cell viability, apoptosis induction, cell cycle arrest, and reactive oxygen species (ROS) production assays were performed. Important proteins and genes related to proliferation and apoptosis were determined. PPE represents a good source of bioactive compounds with a high antioxidant capacity. Cell viability was reduced gradually by PPE treatments, with lower effects in nontumorigenic cells. Compared to the control group, a significant induction of apoptosis as well as cell cycle arrest in the sub-G1 phase and ROS production was observed in PPE-treated cells. Furthermore, the treatment induced the overexpression of p53 at protein levels and upregulated the mRNA expression of pro-apoptotic BAX, CASP9, BID, and CYCS, along with the significant decrease of anti-apoptotic BCL2 gene expression. Simultaneously, cyclin D1 and CDK4 gene expression were significantly decreased, while p21 increased considerably. The treatment also induced the downregulation of Her2 and PI3K at protein levels and caused the suppression of PI3KCA and mTOR expression at gene levels. Overall, these findings suggested that PPE has potential anticancer effects against human colon adenocarcinoma progression.
date: 2026-06
volume: 2026
issue: 1
is part of: Journal of Food Biochemistry
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Valorization of Purple Prickly Pear Peel By‐Products: Antiproliferative and Pro‐Apoptotic Effects on Human Colorectal Cancer Cells HCT116 (Texto)
subject: Nutrition

Valorization of Purple Prickly Pear Peel By‐Products: Antiproliferative and Pro‐Apoptotic Effects on Human Colorectal Cancer Cells HCT116 (Texto)
type: Document
has file: Journal of Food Biochemistry - 2026 - Armas Diaz - Valorization of Purple Prickly Pear Peel By‐Products Antiproliferative.pdf
has part: Journal of Food Biochemistry - 2026 - Armas Diaz - Valorization of Purple Prickly Pear Peel By‐Products Antiproliferative.pdf

Journal of Food Biochemistry
type: Collection
issn: 01458884

José L. Quiles
type: Person
given name: José L.
family name: Quiles

Luca Mazzoni
type: Person
given name: Luca
family name: Mazzoni

Rubén Calderón Iglesias
type: Person
given name: Rubén
family name: Calderón Iglesias

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

Bei Yang
type: Person
given name: Bei
family name: Yang

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Danila Cianciosi
type: Person
given name: Danila
family name: Cianciosi

Zexiu Qi
type: Person
given name: Zexiu
family name: Qi

Massimiliano Gasparrini
type: Person
given name: Massimiliano
family name: Gasparrini

Tamara Y. Forbes-Hernandez
type: Person
given name: Tamara Y.
family name: Forbes-Hernandez

Yasmany Armas Diaz
type: Person
given name: Yasmany
family name: Armas Diaz

HTML Summary of #28586 Valorization of Purple Prickly Pear Peel By‐Products: Antiproliferative and Pro‐Apoptotic Effects on Human Colorectal Cancer Cells HCT116
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primary topic: Valorization of Purple Prickly Pear Peel By‐Products: Antiproliferative and Pro‐Apoptotic Effects on Human Colorectal Cancer Cells HCT116

Nutrition
type: Concept
preferred label: Alimentación @es