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primary topic: Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial

Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial
type: AcademicArticle
type: Article
abstract: Background Periodontitis is a prevalent chronic inflammatory disease in older adults, often linked to systemic conditions and metabolic alterations. Standardized plant extracts may provide consistent adjunctive therapeutic benefits. Purpose and study design This double-blind, randomized, placebo-controlled clinical trial (OLIVAGING; ClinicalTrials.gov: NCT05482373) evaluated whether a standardized olive leaf extract enriched to 40 % oleuropein, given in addition to non-surgical periodontal therapy, improves clinical outcomes and modulates systemic metabolism. Sixty participants aged ≥50 years were randomized to receive either supplement or placebo for 120 days. Primary and secondary outcomes were probing pocket depth (PPD) and clinical attachment level (CAL). Plasma metabolomics was performed using untargeted UHPLC-QTOF-MS. Results Forty-three participants completed the study (23 treatment, 20 placebo). Compared with placebo, the treatment group achieved greater reductions in ΔPPD and gains in ΔCAL across multiple tooth categories and surfaces. Metabolomic profiling revealed distinct Δ patterns, with 17 metabolites differing between groups. Several, including tentatively identified valine, cinnamic acid, 10‑hydroxy-2-decenoic acid, and cortisol, correlated with periodontal improvements, suggesting modulation of biological pathways related to inflammation, oxidative stress, and tissue homeostasis consistent with the know pharmacological effects of oleuropein. Conclusions Adjunctive use of an oleuropein-enriched leaf extract improved clinical periodontal outcomes and modulated systemic metabolic signatures in older adults. The standardized extract ensured therapeutic consistency, while metabolomics provided mechanistic insights into host inflammatory and metabolic responses. Findings support further evaluation of plant-derived bioactives as safe, multi-target adjunctive strategies for periodontitis management.
date: 2026-04
volume: 156
is part of: Phytomedicine
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial (Texto)
has document: Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial (Otro)
subject: Biomedicine
subject: Nutrition

Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial (Texto)
type: Document
has file: 1-s2.0-S0944711326004563-main.pdf
has part: 1-s2.0-S0944711326004563-main.pdf

Phytomedicine
type: Collection
issn: 09447113

Vivian Lipari
type: Person
given name: Vivian
family name: Lipari

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

José L. Quiles
type: Person
given name: José L.
family name: Quiles

Franklin G. Vargas-Corral
type: Person
given name: Franklin G.
family name: Vargas-Corral

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Lorenzo Rivas-García
type: Person
given name: Lorenzo
family name: Rivas-García

Beatriz Bullón
type: Person
given name: Beatriz
family name: Bullón

Pedro Bullón
type: Person
given name: Pedro
family name: Bullón

Tamara Y. Forbes-Hernández
type: Person
given name: Tamara Y.
family name: Forbes-Hernández

Giuseppe Grosso
type: Person
given name: Giuseppe
family name: Grosso

Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial (Otro)
type: Document
is version of: Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial (Texto)
is volatile version of: Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial (Texto)
is index codes version of: Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial (Texto)
has file: indexcodes.txt
has part: indexcodes.txt

http://repositorio.uneatlantico.es/id/eprint/28574/
title: HTML Summary of #28574 Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial
format: text/html
primary topic: Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial

Biomedicine
type: Concept
preferred label: Biomedicina @es

Nutrition
type: Concept
preferred label: Alimentación @es