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primary topic: Dietary EGCG reshapes metabolic-epigenetic interplay to induce transgenerational host defense

Dietary EGCG reshapes metabolic-epigenetic interplay to induce transgenerational host defense
type: AcademicArticle
type: Article
abstract: Introduction Parental diet is a key determinant of offspring health and immune function, in part through epigenetic regulation. Metabolic and epigenetic networks integrate nutrient sensing with chromatin dynamics to maintain cellular and organismal homeostasis. However, the mechanism by which specific dietary bioactive compounds reshape metabolic-epigenetic networks to drive transgenerational adaptive responses remains poorly understood. Objectives Here, we investigate whether and how epigallocatechin-3-gallate (EGCG), a well-characterized dietary bioactive compound, modulates heritable host defense through metabolic-epigenetic crosstalk. Methods To address both physiological relevance and mechanistic insight, we employed mouse and Drosophila melanogaster models. Parental animals were administered EGCG, and offspring were subsequently assessed for immune function upon infection with Escherichia coli, Pseudomonas aeruginosa, or Staphylococcus aureus. By integrating transcriptomics, metabolite analysis, and isotopic tracing, we analyzed metabolism-related pathways and constructed a dynamic network linking metabolic changes to epigenetic modifications in Drosophila. Results In mice, EGCG administration led to a decrease in Escherichia coli burden across multiple tissues in paternal and male offspring in a sex-specific manner, accompanied by metabolic and pro-inflammatory factor changes. In Drosophila melanogaster, early-life EGCG exposure increased survival upon Pseudomonas aeruginosa or Staphylococcus aureus infection and persisted for two subsequent generations. Mechanistically, EGCG reduced intestinal amino acids, thereby moderately inducing activation of activating transcription factor 4 (ATF4), which in turn enhanced maternal glycolysis and immune adaptation. Tyrosine supplementation abolished the enhanced host defense and metabolic changes. Furthermore, ATF4-induced activation of glycolysis promoted ovarian lactate production, serving as a substrate for increased…
date: 2026-04
is part of: Journal of Advanced Research
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Dietary EGCG reshapes metabolic-epigenetic interplay to induce transgenerational host defense (Texto)
subject: Biomedicine
subject: Nutrition

Dietary EGCG reshapes metabolic-epigenetic interplay to induce transgenerational host defense (Texto)
type: Document
has file: 1-s2.0-S2090123226003322-main.pdf
has part: 1-s2.0-S2090123226003322-main.pdf

Journal of Advanced Research
type: Collection
issn: 20901232

Xuanyu Zheng
type: Person
given name: Xuanyu
family name: Zheng

Thomas Efferth
type: Person
given name: Thomas
family name: Efferth

Wenqi Huang
type: Person
given name: Wenqi
family name: Huang

Hui Cao
type: Person
given name: Hui
family name: Cao

Zimiao Chen
type: Person
given name: Zimiao
family name: Chen

Mohamed A. Farag
type: Person
given name: Mohamed A.
family name: Farag

Jianbo Xiao
type: Person
given name: Jianbo
family name: Xiao

Jesus Simal-Gandara
type: Person
given name: Jesus
family name: Simal-Gandara

Shiye Lin
type: Person
given name: Shiye
family name: Lin

HTML Summary of #28494 Dietary EGCG reshapes metabolic-epigenetic interplay to induce transgenerational host defense
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primary topic: Dietary EGCG reshapes metabolic-epigenetic interplay to induce transgenerational host defense

Biomedicine
type: Concept
preferred label: Biomedicina @es

Nutrition
type: Concept
preferred label: Alimentación @es