TY  - JOUR
JF  - Advanced Science
A1  - Wu, Qian
A1  - Zhang, Xingyu
A1  - Zhang, Jingjia
A1  - Huang, Gaohui
A1  - Zhou, Chen
A1  - Li, Chunlin
A1  - Huang, Xiaojun
A1  - Xiao, Jianbo
A1  - Feng, Nianjie
A1  - She, Yuanbin
KW  - intestinal microflora| lignin?carbohydrate complex| polyphenols| ulcerative colitis| W 1 /O/W 2 emulsion
AV  - public
ID  - uneatlantico27827
UR  - http://doi.org/10.1002/advs.202524070
Y1  - 2026/03//
N2  - The therapeutic potential of polyphenols in ulcerative colitis (UC), mediated through immune modulation and gut microbiota homeostasis. To enhance the oral bioavailability of polyphenols, we architected a colon?targeted W1/O/W2 emulsion system featuring a rationally designed lignin?carbohydrate complex (LCC) as a dual?functional emulsifier system for the first time. Based on the innate structural duality of LCC, which comprising hydrophobic lignin and hydrophilic carbohydrates, we employed LCC for O/W emulsifier. This inherent amphiphilicity was further engineered via laccase?mediated grafting of isovanillin, yielding a modified LCC with tailored lipophilicity for effective W/O interfacial stabilization. The W1/O/W2 emulsion ensured the stability of the encapsulated polyphenols with divergent polarity but also enabled pH?responsive payload release under colonic conditions (pH >7.0). In DSS?induced colitis, the system demonstrated a synergistic effect, the LCC itself acted as a prebiotic to modulate the gut microbiota, specifically enriching short chain fatty acid?producing bacteria, while the released polyphenols reinforced the intestinal barrier, which collectively accelerated mucosal healing. This research proposes a carbon?neutral therapeutic strategy for colitis, not only establishing a proof?of?concept for replacing synthetic emulsifiers with engineered biomass, but also as a multi?functional platform to stabilize colon?targeted co?delivery system and microbiome regulation in colitis.
TI  - Constraint of Lignin?Carbohydrate Complex Orchestrated on Polyphenol in Oil?Water Interface Targeting Ulcerative Colitis Therapy
SN  - 2198-3844
ER  -