<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy"^^ . "The therapeutic potential of polyphenols in ulcerative colitis (UC), mediated through immune modulation and gut microbiota homeostasis. To enhance the oral bioavailability of polyphenols, we architected a colon–targeted W1/O/W2 emulsion system featuring a rationally designed lignin–carbohydrate complex (LCC) as a dual–functional emulsifier system for the first time. Based on the innate structural duality of LCC, which comprising hydrophobic lignin and hydrophilic carbohydrates, we employed LCC for O/W emulsifier. This inherent amphiphilicity was further engineered via laccase–mediated grafting of isovanillin, yielding a modified LCC with tailored lipophilicity for effective W/O interfacial stabilization. The W1/O/W2 emulsion ensured the stability of the encapsulated polyphenols with divergent polarity but also enabled pH–responsive payload release under colonic conditions (pH >7.0). In DSS–induced colitis, the system demonstrated a synergistic effect, the LCC itself acted as a prebiotic to modulate the gut microbiota, specifically enriching short chain fatty acid–producing bacteria, while the released polyphenols reinforced the intestinal barrier, which collectively accelerated mucosal healing. This research proposes a carbon–neutral therapeutic strategy for colitis, not only establishing a proof–of–concept for replacing synthetic emulsifiers with engineered biomass, but also as a multi–functional platform to stabilize colon–targeted co–delivery system and microbiome regulation in colitis."^^ . "2026-03" . . . . "Advanced Science"^^ . . . "21983844" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Gaohui"^^ . "Huang"^^ . "Gaohui Huang"^^ . . "Chunlin"^^ . "Li"^^ . "Chunlin Li"^^ . . "Xiaojun"^^ . "Huang"^^ . "Xiaojun Huang"^^ . . "Qian"^^ . "Wu"^^ . "Qian Wu"^^ . . "Jianbo"^^ . "Xiao"^^ . "Jianbo Xiao"^^ . . "Chen"^^ . "Zhou"^^ . "Chen Zhou"^^ . . "Nianjie"^^ . "Feng"^^ . "Nianjie Feng"^^ . . "Jingjia"^^ . "Zhang"^^ . "Jingjia Zhang"^^ . . "Xingyu"^^ . "Zhang"^^ . "Xingyu Zhang"^^ . . "Yuanbin"^^ . "She"^^ . "Yuanbin She"^^ . . . . . . "Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy (Texto)"^^ . . . "Advanced Science - 2026 - Wu - Constraint of Lignin Carbohydrate Complex Orchestrated on Polyphenol in Oil Water Interface.pdf"^^ . . . "Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy (Otro)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #27827 \n\nConstraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy\n\n" . "text/html" . . . "Biomedicine"@en . "Biomedicina"@es . .