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primary topic: Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy
type: AcademicArticle
type: Article
abstract: The therapeutic potential of polyphenols in ulcerative colitis (UC), mediated through immune modulation and gut microbiota homeostasis. To enhance the oral bioavailability of polyphenols, we architected a colon–targeted W1/O/W2 emulsion system featuring a rationally designed lignin–carbohydrate complex (LCC) as a dual–functional emulsifier system for the first time. Based on the innate structural duality of LCC, which comprising hydrophobic lignin and hydrophilic carbohydrates, we employed LCC for O/W emulsifier. This inherent amphiphilicity was further engineered via laccase–mediated grafting of isovanillin, yielding a modified LCC with tailored lipophilicity for effective W/O interfacial stabilization. The W1/O/W2 emulsion ensured the stability of the encapsulated polyphenols with divergent polarity but also enabled pH–responsive payload release under colonic conditions (pH >7.0). In DSS–induced colitis, the system demonstrated a synergistic effect, the LCC itself acted as a prebiotic to modulate the gut microbiota, specifically enriching short chain fatty acid–producing bacteria, while the released polyphenols reinforced the intestinal barrier, which collectively accelerated mucosal healing. This research proposes a carbon–neutral therapeutic strategy for colitis, not only establishing a proof–of–concept for replacing synthetic emulsifiers with engineered biomass, but also as a multi–functional platform to stabilize colon–targeted co–delivery system and microbiome regulation in colitis.
date: 2026-03
is part of: Advanced Science
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy (Texto)
has document: Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy (Otro)
subject: Biomedicine

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy (Texto)
type: Document
has file: Advanced Science - 2026 - Wu - Constraint of Lignin Carbohydrate Complex Orchestrated on Polyphenol in Oil Water Interface.pdf
has part: Advanced Science - 2026 - Wu - Constraint of Lignin Carbohydrate Complex Orchestrated on Polyphenol in Oil Water Interface.pdf

Advanced Science
type: Collection
issn: 21983844

Gaohui Huang
type: Person
given name: Gaohui
family name: Huang

Chunlin Li
type: Person
given name: Chunlin
family name: Li

Xiaojun Huang
type: Person
given name: Xiaojun
family name: Huang

Qian Wu
type: Person
given name: Qian
family name: Wu

Jianbo Xiao
type: Person
given name: Jianbo
family name: Xiao

Chen Zhou
type: Person
given name: Chen
family name: Zhou

Nianjie Feng
type: Person
given name: Nianjie
family name: Feng

Jingjia Zhang
type: Person
given name: Jingjia
family name: Zhang

Xingyu Zhang
type: Person
given name: Xingyu
family name: Zhang

Yuanbin She
type: Person
given name: Yuanbin
family name: She

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy (Otro)
type: Document
is version of: Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy (Texto)
is volatile version of: Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy (Texto)
is index codes version of: Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy (Texto)
has file: indexcodes.txt
has part: indexcodes.txt

HTML Summary of #27827 Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy
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primary topic: Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Biomedicine
type: Concept
preferred label: Biomedicina @es