@article{uneatlantico27827,
         journal = {Advanced Science},
          author = {Qian Wu and Xingyu Zhang and Jingjia Zhang and Gaohui Huang and Chen Zhou and Chunlin Li and Xiaojun Huang and Jianbo Xiao and Nianjie Feng and Yuanbin She},
           month = {Marzo},
           title = {Constraint of Lignin?Carbohydrate Complex Orchestrated on Polyphenol in Oil?Water Interface Targeting Ulcerative Colitis Therapy},
            year = {2026},
        abstract = {The therapeutic potential of polyphenols in ulcerative colitis (UC), mediated through immune modulation and gut microbiota homeostasis. To enhance the oral bioavailability of polyphenols, we architected a colon?targeted W1/O/W2 emulsion system featuring a rationally designed lignin?carbohydrate complex (LCC) as a dual?functional emulsifier system for the first time. Based on the innate structural duality of LCC, which comprising hydrophobic lignin and hydrophilic carbohydrates, we employed LCC for O/W emulsifier. This inherent amphiphilicity was further engineered via laccase?mediated grafting of isovanillin, yielding a modified LCC with tailored lipophilicity for effective W/O interfacial stabilization. The W1/O/W2 emulsion ensured the stability of the encapsulated polyphenols with divergent polarity but also enabled pH?responsive payload release under colonic conditions (pH {\ensuremath{>}}7.0). In DSS?induced colitis, the system demonstrated a synergistic effect, the LCC itself acted as a prebiotic to modulate the gut microbiota, specifically enriching short chain fatty acid?producing bacteria, while the released polyphenols reinforced the intestinal barrier, which collectively accelerated mucosal healing. This research proposes a carbon?neutral therapeutic strategy for colitis, not only establishing a proof?of?concept for replacing synthetic emulsifiers with engineered biomass, but also as a multi?functional platform to stabilize colon?targeted co?delivery system and microbiome regulation in colitis.},
             url = {http://repositorio.uneatlantico.es/id/eprint/27827/},
        keywords = {intestinal microflora{\ensuremath{|}} lignin?carbohydrate complex{\ensuremath{|}} polyphenols{\ensuremath{|}} ulcerative colitis{\ensuremath{|}} W 1 /O/W 2 emulsion}
}