eprintid: 27822 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/02/78/22 datestamp: 2026-03-13 23:30:08 lastmod: 2026-03-13 23:30:10 status_changed: 2026-03-13 23:30:08 type: article metadata_visibility: show creators_name: Martinez, Carlos Rabeiro creators_name: Diaz, Yasmany Armas creators_name: Cianciosi, Danila creators_name: Cao, Qingwei creators_name: Hu, Haixia creators_name: Chen, Ge creators_name: Qi, Zexiu creators_name: Yang, Bei creators_name: Quiles, José L. creators_name: Battino, Maurizio creators_name: Giampieri, Francesca creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: jose.quiles@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es creators_id: francesca.giampieri@uneatlantico.es title: The Health Benefits of Tamarindus indica: A Focus on the Relationship Between Phytochemical Composition and Physiological Effects ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: Tamarindus indica; antioxidants; phenolic compounds; inflammation; cardio-protection; antidiabetic; antibacterial; hepatoprotection abstract: Background/Objectives: Conventional pharmacotherapy for the most prevalent human diseases still has limited efficacy. Natural medicines are recognized for their therapeutic efficacy and low side effects. Tamarindus indica is a tropical tree of the Fabaceae family, valued for its multiple uses and the nutritional properties of its fruits. The purpose of this review is to provide an overview of the nutraceutical value of T. indica, focusing on its phytochemical composition and main health benefits. Methods: For this purpose, a bibliography search was performed in PubMed, Scopus, and ScienceDirect databases, including all articles published between 2000 and December 2025. Results: The T. indica fruit contains different phytochemical compounds, such as flavonoids, tannins, alkaloids, and saponins, with therapeutic potential. These compounds exert free radical scavenging activity, improve antioxidant and detoxification enzyme activities, exert antimicrobial effects, attenuate the activation of pro-inflammatory mediators, and regulate the expression of lipid metabolism genes. Conclusions: This article presents an integrated analysis summarizing the phytochemical characteristics, mode of action, medical utility, and safe use of T. indica, thereby contributing to a greater understanding of its potential health benefits. date: 2026-02 publication: Nutrients volume: 18 number: 4 pagerange: 576 id_number: doi:10.3390/nu18040576 refereed: TRUE issn: 2072-6643 official_url: http://doi.org/10.3390/nu18040576 access: open language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Abierto Inglés Background/Objectives: Conventional pharmacotherapy for the most prevalent human diseases still has limited efficacy. Natural medicines are recognized for their therapeutic efficacy and low side effects. Tamarindus indica is a tropical tree of the Fabaceae family, valued for its multiple uses and the nutritional properties of its fruits. The purpose of this review is to provide an overview of the nutraceutical value of T. indica, focusing on its phytochemical composition and main health benefits. Methods: For this purpose, a bibliography search was performed in PubMed, Scopus, and ScienceDirect databases, including all articles published between 2000 and December 2025. Results: The T. indica fruit contains different phytochemical compounds, such as flavonoids, tannins, alkaloids, and saponins, with therapeutic potential. These compounds exert free radical scavenging activity, improve antioxidant and detoxification enzyme activities, exert antimicrobial effects, attenuate the activation of pro-inflammatory mediators, and regulate the expression of lipid metabolism genes. Conclusions: This article presents an integrated analysis summarizing the phytochemical characteristics, mode of action, medical utility, and safe use of T. indica, thereby contributing to a greater understanding of its potential health benefits. metadata Martinez, Carlos Rabeiro; Diaz, Yasmany Armas; Cianciosi, Danila; Cao, Qingwei; Hu, Haixia; Chen, Ge; Qi, Zexiu; Yang, Bei; Quiles, José L.; Battino, Maurizio y Giampieri, Francesca mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2026) The Health Benefits of Tamarindus indica: A Focus on the Relationship Between Phytochemical Composition and Physiological Effects. Nutrients, 18 (4). p. 576. ISSN 2072-6643 document_url: http://repositorio.uneatlantico.es/id/eprint/27822/1/PIIS0939475325006921.pdf