<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "The SAM-m6A axis as an unexplored therapeutic hub for plant-derived regulation of disease metabolism"^^ . "S-adenosylmethionine (SAM) is the main cellular methyl donor and a core product of one-carbon metabolism. Its balance with S-adenosylhomocysteine (SAH) defines methylation potential and shapes epigenetic and epitranscriptomic outputs. RNA N6-methyladenosine (m6A) directly depends on SAM and is controlled by a writer-reader-eraser system. This review summarizes how altered SAM supply, SAH accumulation, and shifts in the SAM/SAH ratio can reprogram m6A landscapes. These changes can occur in cancer, metabolic disease, inflammation, and neurodegeneration. We integrate metabolic control of SAM generation and consumption with regulation of METTL3/METTL14, WTAP and related cofactors, and the erasers FTO and ALKBH5. We also assess plant-derived bioactive compounds proposed to act on this coupling. Most phytochemicals do not behave as potent, selective m6A enzyme inhibitors. They more often act upstream by reshaping one-carbon metabolism, redox state, and protein expression. This profile contrasts with canonical synthetic inhibitors that block a single node with higher affinity and more predictable pharmacodynamics. Together, the evidence supports the SAM-m6A axis as a practical framework to connect nutrient state with RNA fate decisions. It also highlights key gaps for translation, including target engagement, dose-exposure alignment, and causal validation of m6A-dependent phenotypes."^^ . "2026-02" . . . "225" . . "Pharmacological Research"^^ . . . "10436618" . . . . . . . . . . . . . . . . . . . "Jingyimei"^^ . "Liang"^^ . "Jingyimei Liang"^^ . . "Hui"^^ . "Cao"^^ . "Hui Cao"^^ . . "Jianbo"^^ . "Xiao"^^ . "Jianbo Xiao"^^ . . "Yuxuan"^^ . "Zhao"^^ . "Yuxuan Zhao"^^ . . "Wanning"^^ . "Ma"^^ . "Wanning Ma"^^ . . . . . . "The SAM-m6A axis as an unexplored therapeutic hub for plant-derived regulation of disease metabolism (Texto)"^^ . . . "1-s2.0-S1043661826000290-main.pdf"^^ . . "HTML Summary of #27157 \n\nThe SAM-m6A axis as an unexplored therapeutic hub for plant-derived regulation of disease metabolism\n\n" . "text/html" . . . "Biomedicine"@en . "Biomedicina"@es . .