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primary topic: The SAM-m6A axis as an unexplored therapeutic hub for plant-derived regulation of disease metabolism

The SAM-m6A axis as an unexplored therapeutic hub for plant-derived regulation of disease metabolism
type: AcademicArticle
type: Article
abstract: S-adenosylmethionine (SAM) is the main cellular methyl donor and a core product of one-carbon metabolism. Its balance with S-adenosylhomocysteine (SAH) defines methylation potential and shapes epigenetic and epitranscriptomic outputs. RNA N6-methyladenosine (m6A) directly depends on SAM and is controlled by a writer-reader-eraser system. This review summarizes how altered SAM supply, SAH accumulation, and shifts in the SAM/SAH ratio can reprogram m6A landscapes. These changes can occur in cancer, metabolic disease, inflammation, and neurodegeneration. We integrate metabolic control of SAM generation and consumption with regulation of METTL3/METTL14, WTAP and related cofactors, and the erasers FTO and ALKBH5. We also assess plant-derived bioactive compounds proposed to act on this coupling. Most phytochemicals do not behave as potent, selective m6A enzyme inhibitors. They more often act upstream by reshaping one-carbon metabolism, redox state, and protein expression. This profile contrasts with canonical synthetic inhibitors that block a single node with higher affinity and more predictable pharmacodynamics. Together, the evidence supports the SAM-m6A axis as a practical framework to connect nutrient state with RNA fate decisions. It also highlights key gaps for translation, including target engagement, dose-exposure alignment, and causal validation of m6A-dependent phenotypes.
date: 2026-02
volume: 225
is part of: Pharmacological Research
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: The SAM-m6A axis as an unexplored therapeutic hub for plant-derived regulation of disease metabolism (Texto)
subject: Biomedicine

The SAM-m6A axis as an unexplored therapeutic hub for plant-derived regulation of disease metabolism (Texto)
type: Document
has file: 1-s2.0-S1043661826000290-main.pdf
has part: 1-s2.0-S1043661826000290-main.pdf

Pharmacological Research
type: Collection
issn: 10436618

Jingyimei Liang
type: Person
given name: Jingyimei
family name: Liang

Hui Cao
type: Person
given name: Hui
family name: Cao

Jianbo Xiao
type: Person
given name: Jianbo
family name: Xiao

Yuxuan Zhao
type: Person
given name: Yuxuan
family name: Zhao

Wanning Ma
type: Person
given name: Wanning
family name: Ma

HTML Summary of #27157 The SAM-m6A axis as an unexplored therapeutic hub for plant-derived regulation of disease metabolism
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primary topic: The SAM-m6A axis as an unexplored therapeutic hub for plant-derived regulation of disease metabolism

Biomedicine
type: Concept
preferred label: Biomedicina @es