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primary topic: Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis

Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis
type: AcademicArticle
type: Article
abstract: Objectives To assess the effects of lifestyle interventions on gestational diabetes, determine whether the effects vary by maternal body mass index, age, parity, ethnicity, education level, or intervention, and rank interventions by effectiveness. Design Individual participant data (IPD) and network meta-analysis. Data sources Major electronic databases (January 1990 to April 2025). Methods This meta-analysis included randomised trials on the effects of lifestyle interventions (physical activity based, diet based, or mixed) in pregnancy on gestational diabetes. Main outcomes were gestational diabetes defined by any criteria and by UK NICE (National Institute for Health and Care Excellence) criteria; other outcomes included IADPSG (International Association of Diabetes in Pregnancy Study Group) and modified IADPSG defined gestational diabetes. A two stage IPD meta-analysis estimated summary odds ratios and 95% confidence intervals and interactions (subgroup effects), along with absolute risk reduction estimates. Aggregate data from non-IPD trials were added to the meta-analysis when possible. Intervention effects were ranked using network meta-analysis. Results 104 randomised trials (35 993 women) were included, with IPD for 68% of participants (24 391 women; 54 studies). Lifestyle interventions reduced gestational diabetes defined by any criteria by 10% in IPD trials (odds ratio 0.90, 95% confidence interval (CI) 0.80 to 1.02; absolute risk reduction 1.3%, 95% CI −0.3% to 2.6%), and by 20% when combining IPD and non-IPD trials (odds ratio 0.80, 95% CI 0.73 to 0.88; absolute risk reduction 2.6%, 95% CI 1.6% to 3.6%), and no reduction was observed using NICE criteria (odds ratio 0.98, 95% CI 0.84to 1.13). Lifestyle interventions reduced gestational diabetes defined using IADPSG criteria by 14% in IPD trials (odds ratio 0.86, 95% CI 0.75 to 0.97; absolute risk reduction 2.7%, 95% CI 0.6% to 5.0%) and by 18% when combining IPD and non-IPD trials (odds ratio 0.82, 95% CI…
date: 2026-01
volume: 392
is part of: BMJ
status: peerReviewed
status: published
author list: authors
creator: Mireia Peláez
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis (Texto)
has document: Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis (Otro)
subject: Biomedicine

Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis (Texto)
type: Document
has file: bmj-2025-084159.full.pdf
has part: bmj-2025-084159.full.pdf

BMJ
type: Collection
issn: 17561833

Gabriel Ruiz-Calvo
type: Person
given name: Gabriel
family name: Ruiz-Calvo

Fionnuala M McAuliffe
type: Person
given name: Fionnuala M
family name: McAuliffe

Ghadir Mahmoud
type: Person
given name: Ghadir
family name: Mahmoud

Chidubem Okeke Ogwulu
type: Person
given name: Chidubem Okeke
family name: Ogwulu

Ruben Barakat
type: Person
given name: Ruben
family name: Barakat

Graham A Hitman
type: Person
given name: Graham A
family name: Hitman

Christina Anne Vinter
type: Person
given name: Christina Anne
family name: Vinter

Alka Kothari
type: Person
given name: Alka
family name: Kothari

Mahnaz Bahri Khomami
type: Person
given name: Mahnaz Bahri
family name: Khomami

Tracy Roberts
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given name: Tracy
family name: Roberts

Alfonso L Calle-Pascual
type: Person
given name: Alfonso L
family name: Calle-Pascual

Narges Sadat Motahari-Tabari
type: Person
given name: Narges Sadat
family name: Motahari-Tabari

Helena Teede
type: Person
given name: Helena
family name: Teede

Frances Austin
type: Person
given name: Frances
family name: Austin

Stamatina Iliodromiti
type: Person
given name: Stamatina
family name: Iliodromiti

Anna Boath
type: Person
given name: Anna
family name: Boath

Serena Tonstad
type: Person
given name: Serena
family name: Tonstad

Javier Zamora
type: Person
given name: Javier
family name: Zamora

Mark Monahan
type: Person
given name: Mark
family name: Monahan

Ngawai Moss
type: Person
given name: Ngawai
family name: Moss

Dorte Møller Jensen
type: Person
given name: Dorte Møller
family name: Jensen

Mireia Peláez
type: Person
given name: Mireia
family name: Peláez

Joie Ensor
type: Person
given name: Joie
family name: Ensor

Shakila Thangaratinam
type: Person
given name: Shakila
family name: Thangaratinam

Hans Hauner
type: Person
given name: Hans
family name: Hauner

Sharon Anne Simpson
type: Person
given name: Sharon Anne
family name: Simpson

John Allotey
type: Person
given name: John
family name: Allotey

Krish Nirantharakumar
type: Person
given name: Krish
family name: Nirantharakumar

Min Zheng
type: Person
given name: Min
family name: Zheng

Cheryce Harrison
type: Person
given name: Cheryce
family name: Harrison

Kym J Guelfi
type: Person
given name: Kym J
family name: Guelfi

Fabio Facchinetti
type: Person
given name: Fabio
family name: Facchinetti

Rachel McNeill
type: Person
given name: Rachel
family name: McNeill

Ana Pilar Betrán
type: Person
given name: Ana Pilar
family name: Betrán

Kristina M Renault
type: Person
given name: Kristina M
family name: Renault

Richard D Riley
type: Person
given name: Richard D
family name: Riley

Hollie Meacham
type: Person
given name: Hollie
family name: Meacham

Valencia Kabeya
type: Person
given name: Valencia
family name: Kabeya

Jose G Cecatti
type: Person
given name: Jose G
family name: Cecatti

Suzanne Phelan
type: Person
given name: Suzanne
family name: Phelan

SeonAe Yeo
type: Person
given name: SeonAe
family name: Yeo

Nicola Heslehurst
type: Person
given name: Nicola
family name: Heslehurst

Dyuti Coomar
type: Person
given name: Dyuti
family name: Coomar

Nina Rica Wium Geiker
type: Person
given name: Nina Rica Wium
family name: Geiker

Tarja I Kinnunen
type: Person
given name: Tarja I
family name: Kinnunen

Lucilla Poston
type: Person
given name: Lucilla
family name: Poston

Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis (Otro)
type: Document
is version of: Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis (Texto)
is volatile version of: Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis (Texto)
is index codes version of: Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis (Texto)
has file: indexcodes.txt
has part: indexcodes.txt

HTML Summary of #27155 Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis
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primary topic: Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis

Biomedicine
type: Concept
preferred label: Biomedicina @es