eprintid: 17889 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/01/78/89 datestamp: 2025-12-12 23:30:10 lastmod: 2025-12-12 23:30:11 status_changed: 2025-12-12 23:30:10 type: article metadata_visibility: show creators_name: García-García, Julia creators_name: Rodriguez-Larrad, Ana creators_name: de Rituerto Zeberio, Maren Martinez creators_name: Mediavilla, Jenifer Gómez creators_name: Vicente, Borja López-San creators_name: Artola, Nuria Torrego creators_name: Etxetxipia, Izaskun Zeberio creators_name: Garmendia, Irati creators_name: Alberro, Ainhoa creators_name: Otaegui, David creators_name: Rabasco, Francisco Borrego creators_name: Caffarel, María M. creators_name: Vrotsou, Kalliopi creators_name: Irazusta, Jon creators_name: Arrieta, Haritz creators_name: Peláez, Mireia creators_name: Belloso, Jon creators_name: Basterretxea, Laura creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: mireia.pelaez@uneatlantico.es creators_id: creators_id: title: Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial ispublished: pub subjects: uneat_dp divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: Older adults Cancer Oncogeriatrics Exercise Physical function Frailty Biomarkers Randomised controlled trial abstract: Introduction Cancer in older adults is often associated with functional limitations, geriatric syndromes, poor self-rated health, vulnerability, and frailty, and these conditions might worsen treatment-related side effects. Recent guidelines for patients with cancer during and after treatment have documented the beneficial effects of exercise to counteract certain side effects; however, little is known about the role of exercise during cancer treatment in older adults. Materials and Methods This is a multicentre randomised controlled trial in which 200 participants will be allocated to a control group or an intervention group (the sample size has been calculated to detect a clinical difference of 1 point in Short Physical Performance Battery (SPPB) score, assuming an α error of 0.05, a β error of 0.20, and a 10 % loss rate). Patients aged ≥70 years, diagnosed with any type of solid cancer and candidates for systemic treatment are eligible. Subjects in the intervention group are invited to participate in a 12-week supervised multicomponent exercise programme in addition to receiving usual care. Study assessments are conducted at baseline and three months. The primary outcome measure is physical function as assessed by the SPPB. Secondary outcome measures include comprehensive geriatric assessment scores (including social situation, basic and instrumental activities of daily living, cognitive function, depression, nutritional status, polypharmacy, geriatric syndromes, pain, and emotional distress), anthropometric characteristics, frailty status, physical fitness, physical activity, cognitive function, quality of life, fatigue, and nutritional status. Study assessments also include analysis of inflammatory, endocrine, and nutritional mediators in serum and plasma as potential frailty biomarkers at mRNA and protein levels and multiparametric flow cytometric analysis to measure immunosenescence markers on T and NK cells. Discussion This study seeks to extend our knowledge on exercise interventions during systemic anticancer treatment in patients over 70 years of age. Results from this research will guide the management of older adults during systemic treatment in hospitals seeking to enhance the standard of care. date: 2026-12 publication: Journal of Geriatric Oncology volume: 17 number: 2 pagerange: 102818 id_number: doi:10.1016/j.jgo.2025.102818 refereed: TRUE issn: 18794068 official_url: http://doi.org/10.1016/j.jgo.2025.102818 access: open language: en citation: Artículo Materias > Educación física y el deporte Universidad Europea del Atlántico > Investigación > Artículos y libros Abierto Inglés Introduction Cancer in older adults is often associated with functional limitations, geriatric syndromes, poor self-rated health, vulnerability, and frailty, and these conditions might worsen treatment-related side effects. Recent guidelines for patients with cancer during and after treatment have documented the beneficial effects of exercise to counteract certain side effects; however, little is known about the role of exercise during cancer treatment in older adults. Materials and Methods This is a multicentre randomised controlled trial in which 200 participants will be allocated to a control group or an intervention group (the sample size has been calculated to detect a clinical difference of 1 point in Short Physical Performance Battery (SPPB) score, assuming an α error of 0.05, a β error of 0.20, and a 10 % loss rate). Patients aged ≥70 years, diagnosed with any type of solid cancer and candidates for systemic treatment are eligible. Subjects in the intervention group are invited to participate in a 12-week supervised multicomponent exercise programme in addition to receiving usual care. Study assessments are conducted at baseline and three months. The primary outcome measure is physical function as assessed by the SPPB. Secondary outcome measures include comprehensive geriatric assessment scores (including social situation, basic and instrumental activities of daily living, cognitive function, depression, nutritional status, polypharmacy, geriatric syndromes, pain, and emotional distress), anthropometric characteristics, frailty status, physical fitness, physical activity, cognitive function, quality of life, fatigue, and nutritional status. Study assessments also include analysis of inflammatory, endocrine, and nutritional mediators in serum and plasma as potential frailty biomarkers at mRNA and protein levels and multiparametric flow cytometric analysis to measure immunosenescence markers on T and NK cells. Discussion This study seeks to extend our knowledge on exercise interventions during systemic anticancer treatment in patients over 70 years of age. Results from this research will guide the management of older adults during systemic treatment in hospitals seeking to enhance the standard of care. metadata García-García, Julia; Rodriguez-Larrad, Ana; de Rituerto Zeberio, Maren Martinez; Mediavilla, Jenifer Gómez; Vicente, Borja López-San; Artola, Nuria Torrego; Etxetxipia, Izaskun Zeberio; Garmendia, Irati; Alberro, Ainhoa; Otaegui, David; Rabasco, Francisco Borrego; Caffarel, María M.; Vrotsou, Kalliopi; Irazusta, Jon; Arrieta, Haritz; Peláez, Mireia; Belloso, Jon y Basterretxea, Laura mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, mireia.pelaez@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2026) Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial. Journal of Geriatric Oncology, 17 (2). p. 102818. ISSN 18794068 document_url: http://repositorio.uneatlantico.es/id/eprint/17889/1/PIIS1879406825006344.pdf