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primary topic: Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial

Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial
type: AcademicArticle
type: Article
abstract: Introduction Cancer in older adults is often associated with functional limitations, geriatric syndromes, poor self-rated health, vulnerability, and frailty, and these conditions might worsen treatment-related side effects. Recent guidelines for patients with cancer during and after treatment have documented the beneficial effects of exercise to counteract certain side effects; however, little is known about the role of exercise during cancer treatment in older adults. Materials and Methods This is a multicentre randomised controlled trial in which 200 participants will be allocated to a control group or an intervention group (the sample size has been calculated to detect a clinical difference of 1 point in Short Physical Performance Battery (SPPB) score, assuming an α error of 0.05, a β error of 0.20, and a 10 % loss rate). Patients aged ≥70 years, diagnosed with any type of solid cancer and candidates for systemic treatment are eligible. Subjects in the intervention group are invited to participate in a 12-week supervised multicomponent exercise programme in addition to receiving usual care. Study assessments are conducted at baseline and three months. The primary outcome measure is physical function as assessed by the SPPB. Secondary outcome measures include comprehensive geriatric assessment scores (including social situation, basic and instrumental activities of daily living, cognitive function, depression, nutritional status, polypharmacy, geriatric syndromes, pain, and emotional distress), anthropometric characteristics, frailty status, physical fitness, physical activity, cognitive function, quality of life, fatigue, and nutritional status. Study assessments also include analysis of inflammatory, endocrine, and nutritional mediators in serum and plasma as potential frailty biomarkers at mRNA and protein levels and multiparametric flow cytometric analysis to measure immunosenescence markers on T and NK cells. Discussion This study seeks to extend our knowledg…
date: 2026-12
volume: 17
issue: 2
is part of: Journal of Geriatric Oncology
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial (Texto)
has document: Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial (Otro)
subject: Physical Education and Sport

Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial (Texto)
type: Document
has file: PIIS1879406825006344.pdf
has part: PIIS1879406825006344.pdf

Journal of Geriatric Oncology
type: Collection
issn: 18794068

Julia García-García
type: Person
given name: Julia
family name: García-García

Kalliopi Vrotsou
type: Person
given name: Kalliopi
family name: Vrotsou

Borja López-San Vicente
type: Person
given name: Borja López-San
family name: Vicente

Izaskun Zeberio Etxetxipia
type: Person
given name: Izaskun Zeberio
family name: Etxetxipia

Francisco Borrego Rabasco
type: Person
given name: Francisco Borrego
family name: Rabasco

Jenifer Gómez Mediavilla
type: Person
given name: Jenifer Gómez
family name: Mediavilla

Ainhoa Alberro
type: Person
given name: Ainhoa
family name: Alberro

Laura Basterretxea
type: Person
given name: Laura
family name: Basterretxea

Ana Rodriguez-Larrad
type: Person
given name: Ana
family name: Rodriguez-Larrad

Nuria Torrego Artola
type: Person
given name: Nuria Torrego
family name: Artola

Jon Belloso
type: Person
given name: Jon
family name: Belloso

Jon Irazusta
type: Person
given name: Jon
family name: Irazusta

Haritz Arrieta
type: Person
given name: Haritz
family name: Arrieta

David Otaegui
type: Person
given name: David
family name: Otaegui

Mireia Peláez
type: Person
given name: Mireia
family name: Peláez

María M. Caffarel
type: Person
given name: María M.
family name: Caffarel

Irati Garmendia
type: Person
given name: Irati
family name: Garmendia

Maren Martinez de Rituerto Zeberio
type: Person
given name: Maren Martinez
family name: de Rituerto Zeberio

Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial (Otro)
type: Document
is version of: Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial (Texto)
is volatile version of: Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial (Texto)
is index codes version of: Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial (Texto)
has file: indexcodes.txt
has part: indexcodes.txt

HTML Summary of #17889 Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial
format: text/html
primary topic: Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial

Physical Education and Sport
type: Concept
preferred label: Educación física y el deporte @es