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primary topic: Polyphenols-mediated immune regulation: Metabolite-driven epigenetic regulatory mechanisms

Polyphenols-mediated immune regulation: Metabolite-driven epigenetic regulatory mechanisms
type: AcademicArticle
type: Article
abstract: Background Dietary polyphenols are recognized modulators of immune function. Although metabolic and epigenetic effects have been examined separately, relationships and implications for immune regulation remain unclear. Addressing the gap is critical to understanding how diet shapes immune homeostasis and disease risk. Previous studies examined metabolic and epigenetic effects separately, leaving their interconnections—and implications for immune regulation—unclear. Purpose This review aims to elucidate, from a novel perspective, the polyphenols–metabolic–epigenetic modification–immunity regulatory axis that underlies polyphenols-mediated immunoregulation. By emphasizing this framework, we highlight mechanistic insights into the interplay among diet, metabolism, and immune homeostasis, providing potential strategies for preventing and treating chronic inflammatory and metabolic diseases. Methods A comprehensive search of peer-reviewed publications was performed from core collections of electronic databases such as PubMed, Web of Science, Google Scholar, and Science Direct. Results Polyphenols regulate immunity by reprogramming metabolic pathways and modulating epigenetic mechanisms. Metabolite-driven crosstalk between metabolism and epigenetics offers insights into immune phenotype stability, particularly across generations. These mechanisms are relevant to clinical phenotypes highlighted in the manuscript, including obesity, features of metabolic syndrome, and autoimmune conditions. Challenges remain in translation, including bioavailability, dose-response variability, and limited evidence on transgenerational effects. Future studies should explore how polyphenols-mediated metabolic shifts affect epigenetic regulators during early development and immune inheritance. Integrating polyphenols into immunometabolism and epigenetic regulation offers novel strategies for disease prevention and precision nutrition. Conclusion This review provides a new perspective on polyph…
date: 2025-11
volume: 149
is part of: Phytomedicine
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: Biomedicine

Phytomedicine
type: Collection
issn: 09447113

Quanyong Wu
type: Person
given name: Quanyong
family name: Wu

Boya Ouyang
type: Person
given name: Boya
family name: Ouyang

Jianbo Xiao
type: Person
given name: Jianbo
family name: Xiao

Jingyimei Liang
type: Person
given name: Jingyimei
family name: Liang

Hui Cao
type: Person
given name: Hui
family name: Cao

HTML Summary of #17886 Polyphenols-mediated immune regulation: Metabolite-driven epigenetic regulatory mechanisms
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primary topic: Polyphenols-mediated immune regulation: Metabolite-driven epigenetic regulatory mechanisms

Biomedicine
type: Concept
preferred label: Biomedicina @es