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primary topic: Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms

Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms
type: AcademicArticle
type: Article
abstract: This systematic review included 31 clinical trial articles examining the effects of natural compounds on Alzheimer’s disease (AD) and mild cognitive impairment (MCI), involving 3582 participants aged 50–90. Treatment durations ranged from 8 weeks to 2 years, with an average of 12.5 months. Notably, 11 studies focused on herbal extracts highlighting their prominence in current research. These extracts showed potential cognitive and neuroprotective benefits, although results varied across compounds and study designs. Other natural compounds—including flavonoids, polyphenols, omega-3 fatty acids, Aloe vera, Spirulina, and citrus phytochemicals—may provide cognitive and neuroprotective benefits, with ginseng and Ginkgo biloba combinations also showing promise. Curcumin and Melissa officinalis had limited effects, resveratrol showed mixed outcomes with some side effects, and matcha green tea may improve cognition and sleep quality. Despite generally favorable results, the studies varied considerably in design and quality; nonetheless, herbal extracts represent a prominent category of natural interventions in AD and MCI, underscoring the need for further large-scale, high-quality clinical trials to confirm their therapeutic potential.
date: 2025-10
volume: 26
issue: 21
is part of: International Journal of Molecular Sciences
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms (Texto)
has document: Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms (Otro)
subject: Biomedicine
subject: Nutrition

Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms (Texto)
type: Document
has file: ijms-26-10631-v2.pdf
has part: ijms-26-10631-v2.pdf

International Journal of Molecular Sciences
type: Collection
issn: 14220067

Laura Vera-Ramírez
type: Person
given name: Laura
family name: Vera-Ramírez

José L. Quiles
type: Person
given name: José L.
family name: Quiles

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Vivian Lipari
type: Person
given name: Vivian
family name: Lipari

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

Lorenzo Rivas-García
type: Person
given name: Lorenzo
family name: Rivas-García

Cristina Sánchez-González
type: Person
given name: Cristina
family name: Sánchez-González

Tamara Y. Forbes-Hernández
type: Person
given name: Tamara Y.
family name: Forbes-Hernández

Maria T. Bayo Jimenez
type: Person
given name: Maria T.
family name: Bayo Jimenez

Giuseppe Grosso
type: Person
given name: Giuseppe
family name: Grosso

Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms (Otro)
type: Document
is version of: Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms (Texto)
is volatile version of: Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms (Texto)
is index codes version of: Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms (Texto)
has file: indexcodes.txt
has part: indexcodes.txt

HTML Summary of #17883 Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms
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primary topic: Natural Products in Alzheimer’s Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms

Biomedicine
type: Concept
preferred label: Biomedicina @es

Nutrition
type: Concept
preferred label: Alimentación @es