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primary topic: Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment

Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment
type: AcademicArticle
type: Article
abstract: Background/Objectives: In the present study, ergosterol, a novel natural and animal-free alternative sterol, was investigated, and its effects on liposomal properties were assessed. Importantly, ergosterol’s fungal origin offers a sustainable substitute for cholesterol, aligning with current trends in natural and vegan-friendly formulations. Methods: This study explored the effect of ergosterol content (10 mol% vs. 20 mol%) on the encapsulation efficiency (EE), physical properties, morphology, antioxidant activity, lipid peroxidation, and storage stability of Serpylli herba extract-loaded liposomes. Results: Liposomes with 20 mol% ergosterol exhibited significantly higher EE (~81.0%) than those with 10 mol% (~75.6%), along with improved resistance to UV- and freeze-drying-induced reduction in EE. Extract loading resulted in a reduced particle size, indicating favorable bilayer interactions, whereas lyophilization increased size and polydispersity, reflecting structural destabilization. However, 20 mol% ergosterol improved vesicle uniformity and surface charge stability, suggesting enhanced bilayer rigidity. Zeta potential and mobility trends supported improved colloidal stability in ergosterol-enriched systems under all tested conditions. Over 28 days at 4 °C, non-treated extract-loaded liposomes with a higher ergosterol content demonstrated enhanced vesicle integrity. During storage, UV-treated and lyophilized liposomes with 20 mol% ergosterol maintained more consistent size and charge profiles, indicating better membrane reorganization and stability. Nanoparticle tracking analysis demonstrated that ergosterol content modulates vesicle concentration in a dose-dependent manner, highlighting the role of membrane composition in liposome formation and potential dose uniformity. Transmission electron microscopy analysis of extract-loaded liposomes demonstrated well-defined vesicles with intact structural features. A study in a Franz diffusion cell revealed that ergoster…
date: 2025-10
volume: 17
issue: 11
is part of: Pharmaceutics
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment (Texto)
has document: Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment (Otro)
subject: Biomedicine

Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment (Texto)
type: Document
has file: pharmaceutics-17-01362.pdf
has part: pharmaceutics-17-01362.pdf

Pharmaceutics
type: Collection
issn: 19994923

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

Predrag Petrović
type: Person
given name: Predrag
family name: Petrović

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Dragana Dekanski
type: Person
given name: Dragana
family name: Dekanski

Aleksandra A. Jovanović
type: Person
given name: Aleksandra A.
family name: Jovanović

Ninoslav Mitić
type: Person
given name: Ninoslav
family name: Mitić

Andrea Pirković
type: Person
given name: Andrea
family name: Pirković

Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment (Otro)
type: Document
is version of: Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment (Texto)
is volatile version of: Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment (Texto)
is index codes version of: Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment (Texto)
has file: indexcodes.txt
has part: indexcodes.txt

HTML Summary of #17882 Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment
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primary topic: Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment

Biomedicine
type: Concept
preferred label: Biomedicina @es