TY - JOUR JF - Cancer Medicine TI - Factors Associated With Employment and Quality of Working Life in Patients With Metastatic Breast Cancer AV - public A1 - Kias, Alina A1 - Schmidt, Martina E. A1 - Hiensch, Anouk E. A1 - Clauss, Dorothea A1 - Monninkhof, Evelyn M. A1 - Peláez, Mireia A1 - Belloso, Jon A1 - Gunasekara, Nadira A1 - Sweegers, Maike G. A1 - Trevaskis, Mark A1 - Rundqvist, Helene A1 - Müller, Jana A1 - Wiskemann, Joachim A1 - van der Wall, Elsken A1 - Aaronson, Neil K. A1 - Lachowicz, Milena A1 - Urruticoechea, Ander A1 - Zopf, Eva M. A1 - Bloch, Wilhelm A1 - Stuiver, Martijn M. A1 - Wengström, Yvonne A1 - May, Anne M. A1 - Steindorf, Karen VL - 14 N2 - Purpose As survival of patients with metastatic breast cancer (MBC) improves, their work situation is gaining importance. The aim of the current study was to identify factors associated with work status and quality of working life (QWL) in patients with MBC. Additionally, we investigated the effects of an exercise intervention on work status. Methods Within the multinational PREFERABLE-EFFECT exercise trial, 287 patients with MBC of working age (18?65?years) reported on their working situation over 9?months as a secondary endpoint. Among a subgroup of participants, QWL was assessed by the Quality of Working Life Questionnaire for Cancer Survivors (QWLQ-CS) (N?=?59). Results At baseline, 157 (54.7%) participants were employed, of whom one-third reported having recently reduced their amount of work because of fatigue (41.7%), cognitive problems (33.3%), or inability to meet work demands (33.3%). Participants wished for more flexible working hours (29.2%) and less productivity pressure (37.5%). Participants were less likely to work if they experienced higher levels of pain (p?=?0.014). Among working participants, an academic education and higher levels of psychological distress were associated with a higher number of working hours (all p?