eprintid: 17813 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/01/78/13 datestamp: 2025-06-24 23:30:07 lastmod: 2025-06-24 23:30:09 status_changed: 2025-06-24 23:30:07 type: article metadata_visibility: show creators_name: Sotelo, Marta creators_name: Peláez, Mireia creators_name: Basterretxea, Laura creators_name: Varga, Estrella creators_name: Sánchez-Escribano, Ricardo creators_name: Pujol Obis, Eduardo creators_name: Santander, Carmen creators_name: Martínez Kareaga, Mireia creators_name: Arruti Ibarbia, Mikel creators_name: Rodríguez Ledesma, Inmaculada creators_name: Álvarez Fernández, Carlos creators_name: Piedra, Pablo creators_name: Calderero Aragón, Verónica creators_name: Lainez, Nuria creators_name: Verdún Aguilar, Juan Antonio creators_name: Gil Arnáiz, Irene creators_name: Fernández, Ricardo creators_name: Mazas Pérez-Oleaga, Cristina creators_name: Duran, Ignacio creators_id: creators_id: mireia.pelaez@uneatlantico.es creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: cristina.mazas@uneatlantico.es creators_id: title: Avelumab maintenance in advanced urothelial carcinoma: real-world data from Northern Spain (AVEBLADDER study) ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: Avelumab; Locally advanced/metastatic urothelial cancer; Treatment outcomes; Real-world data abstract: Background Before the incorporation of enfortumab vedotin with pembrolizumab, the standard of care for patients with locally advanced or metastatic urothelial carcinoma who do not progress after platinum-based chemotherapy was avelumab maintenance therapy, as demonstrated by the JAVELIN 100 trial. However, real-world European data remain scarce. Patients and Methods AVEBLADDER is a retrospective study conducted at 14 hospitals in Northern Spain, including patients with locally advanced or metastatic urothelial carcinoma diagnosed between January 2021 and June 2023. Outcomes of overall survival (OS) and progression-free survival (PFS) were analyzed for patients treated with platinum-based chemotherapy, with and without subsequent avelumab maintenance therapy. non-avelumab patients. Median PFS was 11.33 months (95% CI: 10–13.6) with avelumab and 6.43 months (95% CI: 6–7.6) without. One-year OS probabilities were 81.6% vs. 45.6% (p < 0.001) in the avelumab and non-avelumab groups, respectively. No unexpected toxicities were reported. Conclusions Despite proven survival benefits, avelumab uptake in real-world practice is limited by barriers like access, reimbursement, and awareness. These findings align with JAVELIN 100 and underscore the need for further real-world studies to address treatment disparities. date: 2025-06 publication: Clinical and Translational Oncology id_number: doi:10.1007/s12094-025-03950-w refereed: TRUE issn: 1699-3055 official_url: http://doi.org/10.1007/s12094-025-03950-w access: open language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Artículos y libros Abierto Inglés Background Before the incorporation of enfortumab vedotin with pembrolizumab, the standard of care for patients with locally advanced or metastatic urothelial carcinoma who do not progress after platinum-based chemotherapy was avelumab maintenance therapy, as demonstrated by the JAVELIN 100 trial. However, real-world European data remain scarce. Patients and Methods AVEBLADDER is a retrospective study conducted at 14 hospitals in Northern Spain, including patients with locally advanced or metastatic urothelial carcinoma diagnosed between January 2021 and June 2023. Outcomes of overall survival (OS) and progression-free survival (PFS) were analyzed for patients treated with platinum-based chemotherapy, with and without subsequent avelumab maintenance therapy. non-avelumab patients. Median PFS was 11.33 months (95% CI: 10–13.6) with avelumab and 6.43 months (95% CI: 6–7.6) without. One-year OS probabilities were 81.6% vs. 45.6% (p < 0.001) in the avelumab and non-avelumab groups, respectively. No unexpected toxicities were reported. Conclusions Despite proven survival benefits, avelumab uptake in real-world practice is limited by barriers like access, reimbursement, and awareness. These findings align with JAVELIN 100 and underscore the need for further real-world studies to address treatment disparities. metadata Sotelo, Marta; Peláez, Mireia; Basterretxea, Laura; Varga, Estrella; Sánchez-Escribano, Ricardo; Pujol Obis, Eduardo; Santander, Carmen; Martínez Kareaga, Mireia; Arruti Ibarbia, Mikel; Rodríguez Ledesma, Inmaculada; Álvarez Fernández, Carlos; Piedra, Pablo; Calderero Aragón, Verónica; Lainez, Nuria; Verdún Aguilar, Juan Antonio; Gil Arnáiz, Irene; Fernández, Ricardo; Mazas Pérez-Oleaga, Cristina y Duran, Ignacio mail SIN ESPECIFICAR, mireia.pelaez@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, cristina.mazas@uneatlantico.es, SIN ESPECIFICAR (2025) Avelumab maintenance in advanced urothelial carcinoma: real-world data from Northern Spain (AVEBLADDER study). Clinical and Translational Oncology. ISSN 1699-3055 document_url: http://repositorio.uneatlantico.es/id/eprint/17813/1/s12094-025-03950-w.pdf