@article{uneatlantico17813,
            year = {2025},
          author = {Marta Sotelo and Mireia Pel{\'a}ez and Laura Basterretxea and Estrella Varga and Ricardo S{\'a}nchez-Escribano and Eduardo Pujol Obis and Carmen Santander and Mireia Mart{\'i}nez Kareaga and Mikel Arruti Ibarbia and Inmaculada Rodr{\'i}guez Ledesma and Carlos {\'A}lvarez Fern{\'a}ndez and Pablo Piedra and Ver{\'o}nica Calderero Arag{\'o}n and Nuria Lainez and Juan Antonio Verd{\'u}n Aguilar and Irene Gil Arn{\'a}iz and Ricardo Fern{\'a}ndez and Cristina Mazas P{\'e}rez-Oleaga and Ignacio Duran},
           title = {Avelumab maintenance in advanced urothelial carcinoma: real-world data from Northern Spain (AVEBLADDER study)},
           month = {Junio},
         journal = {Clinical and Translational Oncology},
        abstract = {Background
Before the incorporation of enfortumab vedotin with pembrolizumab, the standard of care for patients with locally advanced or metastatic urothelial carcinoma who do not progress after platinum-based chemotherapy was avelumab maintenance therapy, as demonstrated by the JAVELIN 100 trial. However, real-world European data remain scarce.

Patients and Methods
AVEBLADDER is a retrospective study conducted at 14 hospitals in Northern Spain, including patients with locally advanced or metastatic urothelial carcinoma diagnosed between January 2021 and June 2023. Outcomes of overall survival (OS) and progression-free survival (PFS) were analyzed for patients treated with platinum-based chemotherapy, with and without subsequent avelumab maintenance therapy. non-avelumab patients. Median PFS was 11.33 months (95\% CI: 10?13.6) with avelumab and 6.43 months (95\% CI: 6?7.6) without. One-year OS probabilities were 81.6\% vs. 45.6\% (p {\ensuremath{<}} 0.001) in the avelumab and non-avelumab groups, respectively. No unexpected toxicities were reported.

Conclusions
Despite proven survival benefits, avelumab uptake in real-world practice is limited by barriers like access, reimbursement, and awareness. These findings align with JAVELIN 100 and underscore the need for further real-world studies to address treatment disparities.},
             url = {http://repositorio.uneatlantico.es/id/eprint/17813/},
        keywords = {Avelumab; Locally advanced/metastatic urothelial cancer; Treatment outcomes; Real-world data}
}