TY - JOUR TI - UPLC-ESI-MS/MS-based chemometric approach for investigating the effect of conventional versus modern extraction methods on polyphenols recovery from grape seed wastes AV - none SN - 03088146 Y1 - 2025/05// JF - Food Chemistry N2 - Grape seed wastes are a rich source of bioactive polyphenols. This study compares the recovery efficiency of traditional maceration extraction (ME) with modern extraction techniques (ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and accelerated solvent extraction (ASE)), revealing the selective extraction of polyphenolic compounds by different methods. UPLC-ESI-MS/MS analysis was used to identify and quantify 24 polyphenols. ASE showed the highest efficiency for phenolic acids (e.g., gallic acid, 231.75 ?g/g) and proanthocyanidins (e.g., procyanidin B1, 126.18 ?g/g), while MAE was optimal for flavonoids recovery (e.g., myricetin, 41.52 ?g/g). Multivariate chemometric analysis revealed co-extraction patterns among structurally related compounds (e.g., flavan-3-ols with galloylated derivatives), linking extraction parameters to the selectivity of polyphenols. Integrating UPLC-ESI-MS/MS profiling of 24 polyphenols, we suggest that MAE/ASE is most suitable for antioxidant-rich nutraceuticals, while ME is optimal for thermally labile pharmaceuticals. This study provides practical strategies for the sustainable utilization of grape seed by-products, offering industry-specific solutions to reduce waste and improve the recovery of bioactive compounds. VL - 487 A1 - Chen, Shengxiong A1 - Yuan, Yi A1 - Zhang, Fan A1 - Lin, Shiye A1 - Zou, Pengren A1 - Farag, Mohamed A. A1 - Simal-Gandara, Jesus A1 - Cao, Hui A1 - Xiao, Jianbo ID - uneatlantico17800 UR - http://doi.org/10.1016/j.foodchem.2025.144619 ER -