TY  - JOUR
TI  - UPLC-ESI-MS/MS-based chemometric approach for investigating the effect of conventional versus modern extraction methods on polyphenols recovery from grape seed wastes
AV  - none
SN  - 03088146
Y1  - 2025/05//
JF  - Food Chemistry
N2  - Grape seed wastes are a rich source of bioactive polyphenols. This study compares the recovery efficiency of traditional maceration extraction (ME) with modern extraction techniques (ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and accelerated solvent extraction (ASE)), revealing the selective extraction of polyphenolic compounds by different methods. UPLC-ESI-MS/MS analysis was used to identify and quantify 24 polyphenols. ASE showed the highest efficiency for phenolic acids (e.g., gallic acid, 231.75 ?g/g) and proanthocyanidins (e.g., procyanidin B1, 126.18 ?g/g), while MAE was optimal for flavonoids recovery (e.g., myricetin, 41.52 ?g/g). Multivariate chemometric analysis revealed co-extraction patterns among structurally related compounds (e.g., flavan-3-ols with galloylated derivatives), linking extraction parameters to the selectivity of polyphenols. Integrating UPLC-ESI-MS/MS profiling of 24 polyphenols, we suggest that MAE/ASE is most suitable for antioxidant-rich nutraceuticals, while ME is optimal for thermally labile pharmaceuticals. This study provides practical strategies for the sustainable utilization of grape seed by-products, offering industry-specific solutions to reduce waste and improve the recovery of bioactive compounds.
VL  - 487
A1  - Chen, Shengxiong
A1  - Yuan, Yi
A1  - Zhang, Fan
A1  - Lin, Shiye
A1  - Zou, Pengren
A1  - Farag, Mohamed A.
A1  - Simal-Gandara, Jesus
A1  - Cao, Hui
A1  - Xiao, Jianbo
ID  - uneatlantico17800
UR  - http://doi.org/10.1016/j.foodchem.2025.144619
ER  -