<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "UPLC-ESI-MS/MS-based chemometric approach for investigating the effect of conventional versus modern extraction methods on polyphenols recovery from grape seed wastes"^^ . "Grape seed wastes are a rich source of bioactive polyphenols. This study compares the recovery efficiency of traditional maceration extraction (ME) with modern extraction techniques (ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and accelerated solvent extraction (ASE)), revealing the selective extraction of polyphenolic compounds by different methods. UPLC-ESI-MS/MS analysis was used to identify and quantify 24 polyphenols. ASE showed the highest efficiency for phenolic acids (e.g., gallic acid, 231.75 μg/g) and proanthocyanidins (e.g., procyanidin B1, 126.18 μg/g), while MAE was optimal for flavonoids recovery (e.g., myricetin, 41.52 μg/g). Multivariate chemometric analysis revealed co-extraction patterns among structurally related compounds (e.g., flavan-3-ols with galloylated derivatives), linking extraction parameters to the selectivity of polyphenols. Integrating UPLC-ESI-MS/MS profiling of 24 polyphenols, we suggest that MAE/ASE is most suitable for antioxidant-rich nutraceuticals, while ME is optimal for thermally labile pharmaceuticals. This study provides practical strategies for the sustainable utilization of grape seed by-products, offering industry-specific solutions to reduce waste and improve the recovery of bioactive compounds."^^ . "2025-05" . . "487" . . "Food Chemistry"^^ . . . "03088146" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Hui"^^ . "Cao"^^ . "Hui Cao"^^ . . "Fan"^^ . "Zhang"^^ . "Fan Zhang"^^ . . "Shengxiong"^^ . "Chen"^^ . "Shengxiong Chen"^^ . . "Yi"^^ . "Yuan"^^ . "Yi Yuan"^^ . . "Shiye"^^ . "Lin"^^ . "Shiye Lin"^^ . . "Pengren"^^ . "Zou"^^ . "Pengren Zou"^^ . . "Jianbo"^^ . "Xiao"^^ . "Jianbo Xiao"^^ . . "Jesus"^^ . "Simal-Gandara"^^ . "Jesus Simal-Gandara"^^ . . "Mohamed A."^^ . "Farag"^^ . "Mohamed A. Farag"^^ . . . . . "HTML Summary of #17800 \n\nUPLC-ESI-MS/MS-based chemometric approach for investigating the effect of conventional versus modern extraction methods on polyphenols recovery from grape seed wastes\n\n" . "text/html" . . . "Engineering"@en . "Ingeniería"@es . . . "Nutrition"@en . "Alimentación"@es . .