TY  - JOUR
ID  - uneatlantico176
TI  - Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing
EP  - 49
PB  - ELSEVIER
KW  - Manuka honey
KW  -  ROSAMPK
KW  -  Nrf2Wound healing
A1  - Alvarez-Suarez, José Miguel
A1  - Giampieri, Francesca
A1  - Cordero, Mario
A1  - Gasparrini, Massimiliano
A1  - Forbes-Hernandez, Tamara Yuliet
A1  - Mazzoni, Luca
A1  - Afrin, Sadia
A1  - Beltrán-Ayala, Pablo
A1  - González-Paramás, Ana María
A1  - Santos-Buelga, Celestino
A1  - Varela-Lopez, Alfonso
A1  - Quiles, José Luis
A1  - Battino, Maurizio
AV  - none
SP  - 38
N2  - Excessive amounts of free radicals are deleterious for cells, resulting in cell damage, affecting the wound healing process and causing premature ageing or even neoplastic transformation. Here the capacity of Manuka honey (MH) to protect against oxidative damage and improve the process of skin wound healing was investigated. Up to 16 compounds were identified in MH, with leptosin derivatives and methyl syringate as the major ones. MH protected against apoptosis, intracellular ROS production, and lipid and protein oxidative damage. MH also protected mitochondrial functionality, promoted cell proliferation and activated the AMPK/Nrf2/ARE signalling pathway, as well as the expression of the antioxidant enzymes such as SOD and CAT. Here we describe for the first time that one of the possible mechanisms by which MH exhibits its ability to promote wound healing could be due to its capacity to improve the antioxidant response by activating AMPK phosphorylation and the ARE response.
JF  - Journal of Functional Foods
Y1  - 2016///
SN  - 1756-4646
UR  - http://doi.org/10.1016/j.jff.2016.05.008
VL  - 25
ER  -