eprintid: 17541 rev_number: 9 eprint_status: archive userid: 2 dir: disk0/00/01/75/41 datestamp: 2025-04-08 23:30:09 lastmod: 2025-04-08 23:30:10 status_changed: 2025-04-08 23:30:09 type: article metadata_visibility: show creators_name: Cassotta, Manuela creators_name: Armas Diaz, Yasmany creators_name: Qi, Zexiu creators_name: Yang, Bei creators_name: Grosso, Giuseppe creators_name: Quiles, José L. creators_name: Battino, Maurizio creators_name: Godos, Justyna creators_name: Giampieri, Francesca creators_id: manucassotta@gmail.com creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: maurizio.battino@uneatlantico.es creators_id: creators_id: francesca.giampieri@uneatlantico.es title: Modernizing gut-brain axis research in nutritional Science: The role of human-centered New Approach Methodologies ispublished: pub subjects: uneat_bm subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: Gut-brain axis; Nutrition; Organoids; Organs-on-chip; Omics abstract: Background The gut-brain axis is a complex communication network that connects the gastrointestinal system with the central nervous system, significantly influencing various health outcomes, such as mental health, cognitive function, metabolic regulation, and immune responses. While traditional research models, particularly animal studies, have provided valuable insights, they often overlook the intricate and human-specific interactions within this axis. Consequently, translating findings from these models into clinical applications has been challenging. However, recent advancements in human-based Novel Approach Methodologies (NAMs), like organoids, organs-on-chip, and omic sciences, present innovative tools for investigating the gut-brain axis with improved accuracy and relevance to human physiology. These methodologies facilitate a deeper understanding of the molecular and cellular mechanisms by which nutritional interventions affect not only mental health but also a wider range of gut-brain-related health outcomes. Scope and approach: Scope and approach: This paper explores how NAMs are revolutionizing gut-brain axis research by providing more accurate models that replicate human physiology, thereby replacing less effective traditional approaches. Key findings and conclusion By using these advanced methods, researchers can produce detailed data that better mirror human responses to dietary components, resulting in more effective and personalized strategies for managing and enhancing gut-brain health. Future research should concentrate on utilizing NAMs to deepen our understanding of the gut-brain axis in nutritional science, which will ultimately lead to more targeted and effective health interventions for various conditions. date: 2025-03 publication: Trends in Food Science & Technology volume: 159 pagerange: 104980 id_number: doi:10.1016/j.tifs.2025.104980 refereed: TRUE issn: 09242244 official_url: http://doi.org/10.1016/j.tifs.2025.104980 access: open language: en citation: Artículo Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Abierto Inglés Background The gut-brain axis is a complex communication network that connects the gastrointestinal system with the central nervous system, significantly influencing various health outcomes, such as mental health, cognitive function, metabolic regulation, and immune responses. While traditional research models, particularly animal studies, have provided valuable insights, they often overlook the intricate and human-specific interactions within this axis. Consequently, translating findings from these models into clinical applications has been challenging. However, recent advancements in human-based Novel Approach Methodologies (NAMs), like organoids, organs-on-chip, and omic sciences, present innovative tools for investigating the gut-brain axis with improved accuracy and relevance to human physiology. These methodologies facilitate a deeper understanding of the molecular and cellular mechanisms by which nutritional interventions affect not only mental health but also a wider range of gut-brain-related health outcomes. Scope and approach: Scope and approach: This paper explores how NAMs are revolutionizing gut-brain axis research by providing more accurate models that replicate human physiology, thereby replacing less effective traditional approaches. Key findings and conclusion By using these advanced methods, researchers can produce detailed data that better mirror human responses to dietary components, resulting in more effective and personalized strategies for managing and enhancing gut-brain health. Future research should concentrate on utilizing NAMs to deepen our understanding of the gut-brain axis in nutritional science, which will ultimately lead to more targeted and effective health interventions for various conditions. metadata Cassotta, Manuela; Armas Diaz, Yasmany; Qi, Zexiu; Yang, Bei; Grosso, Giuseppe; Quiles, José L.; Battino, Maurizio; Godos, Justyna y Giampieri, Francesca mail manucassotta@gmail.com, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es (2025) Modernizing gut-brain axis research in nutritional Science: The role of human-centered New Approach Methodologies. Trends in Food Science & Technology, 159. p. 104980. ISSN 09242244 document_url: http://repositorio.uneatlantico.es/id/eprint/17541/1/1-s2.0-S0924224425001165-main.pdf