relation: http://repositorio.uneatlantico.es/id/eprint/17541/ canonical: http://repositorio.uneatlantico.es/id/eprint/17541/ title: Modernizing gut-brain axis research in nutritional Science: The role of human-centered New Approach Methodologies creator: Cassotta, Manuela creator: Armas Diaz, Yasmany creator: Qi, Zexiu creator: Yang, Bei creator: Grosso, Giuseppe creator: Quiles, José L. creator: Battino, Maurizio creator: Godos, Justyna creator: Giampieri, Francesca subject: Biomedicina subject: Alimentación description: Background The gut-brain axis is a complex communication network that connects the gastrointestinal system with the central nervous system, significantly influencing various health outcomes, such as mental health, cognitive function, metabolic regulation, and immune responses. While traditional research models, particularly animal studies, have provided valuable insights, they often overlook the intricate and human-specific interactions within this axis. Consequently, translating findings from these models into clinical applications has been challenging. However, recent advancements in human-based Novel Approach Methodologies (NAMs), like organoids, organs-on-chip, and omic sciences, present innovative tools for investigating the gut-brain axis with improved accuracy and relevance to human physiology. These methodologies facilitate a deeper understanding of the molecular and cellular mechanisms by which nutritional interventions affect not only mental health but also a wider range of gut-brain-related health outcomes. Scope and approach: Scope and approach: This paper explores how NAMs are revolutionizing gut-brain axis research by providing more accurate models that replicate human physiology, thereby replacing less effective traditional approaches. Key findings and conclusion By using these advanced methods, researchers can produce detailed data that better mirror human responses to dietary components, resulting in more effective and personalized strategies for managing and enhancing gut-brain health. Future research should concentrate on utilizing NAMs to deepen our understanding of the gut-brain axis in nutritional science, which will ultimately lead to more targeted and effective health interventions for various conditions. date: 2025-03 type: Artículo type: PeerReviewed format: text language: en rights: cc_by_4 identifier: http://repositorio.uneatlantico.es/id/eprint/17541/1/1-s2.0-S0924224425001165-main.pdf identifier: Artículo Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Abierto Inglés Background The gut-brain axis is a complex communication network that connects the gastrointestinal system with the central nervous system, significantly influencing various health outcomes, such as mental health, cognitive function, metabolic regulation, and immune responses. While traditional research models, particularly animal studies, have provided valuable insights, they often overlook the intricate and human-specific interactions within this axis. Consequently, translating findings from these models into clinical applications has been challenging. However, recent advancements in human-based Novel Approach Methodologies (NAMs), like organoids, organs-on-chip, and omic sciences, present innovative tools for investigating the gut-brain axis with improved accuracy and relevance to human physiology. These methodologies facilitate a deeper understanding of the molecular and cellular mechanisms by which nutritional interventions affect not only mental health but also a wider range of gut-brain-related health outcomes. Scope and approach: Scope and approach: This paper explores how NAMs are revolutionizing gut-brain axis research by providing more accurate models that replicate human physiology, thereby replacing less effective traditional approaches. Key findings and conclusion By using these advanced methods, researchers can produce detailed data that better mirror human responses to dietary components, resulting in more effective and personalized strategies for managing and enhancing gut-brain health. Future research should concentrate on utilizing NAMs to deepen our understanding of the gut-brain axis in nutritional science, which will ultimately lead to more targeted and effective health interventions for various conditions. metadata Cassotta, Manuela; Armas Diaz, Yasmany; Qi, Zexiu; Yang, Bei; Grosso, Giuseppe; Quiles, José L.; Battino, Maurizio; Godos, Justyna y Giampieri, Francesca mail manucassotta@gmail.com, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es (2025) Modernizing gut-brain axis research in nutritional Science: The role of human-centered New Approach Methodologies. Trends in Food Science & Technology, 159. p. 104980. ISSN 09242244 relation: http://doi.org/10.1016/j.tifs.2025.104980 relation: doi:10.1016/j.tifs.2025.104980 language: en