TY  - JOUR
TI  - Intergenerational inheritance of quercetin-induced abnormal immunity in mice
EP  - 12
UR  - http://doi.org/10.1080/10408398.2025.2474181
SP  - 1
A1  - Zheng, Xuanyu
A1  - Huang, Wenqi
A1  - Farag, Mohamed A.
A1  - Xiao, Jianbo
A1  - Li, Chunlin
ID  - uneatlantico17393
JF  - Critical Reviews in Food Science and Nutrition
AV  - none
SN  - 1040-8398
N2  - Quercetin, a dietary flavonol enriched in food, regulates immune-related models through epigenetic modifications. However, few studies have explored the transmission of regulatory effects across generations to the progeny. Here, we selected Escherichia coli, a conditional pathogen capable of causing gastrointestinal infections or various localized tissue and organ infections under specific conditions, as the pathogenic strain to infect mice. We provide evidence that quercetin can not only induce responsiveness changes against systemic E. coli infection in directly exposed organisms, but also in subsequent generations through the transgenerational inheritance of epigenetic traits. Both parental male mice and their progeny exhibited cellular and phenotypic changes associated with metabolic alterations. Surprisingly, the male and female progeny of mice treated with quercetin (200?mg/kg) for six weeks negatively enhanced the survival rate under systemic E. coli (1?×?108 CFU/mL) infection, concurrent with an increase in bacterial loads in the liver and spleen. Serum TNF-? and IL-1? levels significantly increased post-infection in the progeny. Our results provide the first evidence of the inheritance of immunity driven by quercetin in mammals and the attenuation of protection against bacterial infection.
KW  - Quercetin; intergenerational inheritance; epigenetic; immune function; infection
Y1  - 2025/03//
ER  -