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Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Thyroid illness encompasses a range of disorders affecting the thyroid gland, leading to either hyperthyroidism or hypothyroidism, which can significantly impact metabolism and overall health. Hypothyroidism can cause a slowdown in bodily processes, leading to symptoms such as fatigue, weight gain, depression, and cold sensitivity. Hyperthyroidism can lead to increased metabolism, causing symptoms like rapid weight loss, anxiety, irritability, and heart palpitations. Prompt diagnosis and appropriate treatment are crucial in managing thyroid disorders and improving patients’ quality of life. Thyroid illness affects millions worldwide and can significantly impact their quality of life if left untreated. This research aims to propose an effective artificial intelligence-based approach for the early diagnosis of thyroid illness. An open-access thyroid disease dataset based on 3,772 male and female patient observations is used for this research experiment. This study uses the nominal continuous synthetic minority oversampling technique (SMOTE-NC) for data balancing and a fine-tuned light gradient booster machine (LGBM) technique to diagnose thyroid illness and handle class imbalance problems. The proposed SNL (SMOTE-NC-LGBM) approach outperformed the state-of-the-art approach with high-accuracy performance scores of 0.96. We have also applied advanced machine learning and deep learning methods for comparison to evaluate performance. Hyperparameter optimizations are also conducted to enhance thyroid diagnosis performance. In addition, we have applied the explainable Artificial Intelligence (XAI) mechanism based on Shapley Additive exPlanations (SHAP) to enhance the transparency and interpretability of the proposed method by analyzing the decision-making processes. The proposed research revolutionizes the diagnosis of thyroid disorders efficiently and helps specialties overcome thyroid disorders early. metadata Raza, Ali; Eid, Fatma; Caro Montero, Elisabeth; Delgado Noya, Irene y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, elizabeth.caro@uneatlantico.es, irene.delgado@uneatlantico.es, SIN ESPECIFICAR (2024) Enhanced interpretable thyroid disease diagnosis by leveraging synthetic oversampling and machine learning models. BMC Medical Informatics and Decision Making, 24 (1). ISSN 1472-6947