eprintid: 145 rev_number: 9 eprint_status: archive userid: 2 importid: 0 dir: disk0/00/00/01/45 datestamp: 2021-06-01 23:55:14 lastmod: 2022-01-19 23:55:06 status_changed: 2021-06-01 23:55:14 type: article succeeds: 0 commentary: 0 metadata_visibility: show item_issues_count: 0 sword_depositor: 0 creators_name: Pistollato, Francesca creators_name: Calderón Iglesias, Rubén creators_name: Ruiz Salces, Roberto creators_name: Aparicio Obregón, Silvia creators_name: Crespo Alvare, Jorge creators_name: Dzul Lopez, Luis creators_name: Giampieri, Francesca creators_name: Battino, Maurizio creators_id: creators_id: ruben.calderon@uneatlantico.es creators_id: roberto.ruiz@uneatlantico.es creators_id: silvia.aparicio@uneatlantico.es creators_id: jorge.crespo@uneatlantico.es creators_id: luis.dzul@unini.edu.mx creators_id: creators_id: maurizio.battino@uneatlantico.es title: The use of natural compounds for the targeting and chemoprevention of ovarian cancer ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica full_text_status: none keywords: Ovarian cancer; Chemotherapy resistance; Natural compounds; Autophagy; Apoptosis; Ovarian cancer stem-like cells. abstract: Among gynaecological cancers, ovarian cancer represents the leading cause of death in women. Current treatment for ovarian cancer entails surgery followed by combined chemotherapy with platinum and taxane, which are associated, particularly cisplatin, with severe side effects. While this treatment approach appears to be initially effective in a high number of patients, nearly 70% of them suffer a relapse within a few months after initial treatment. Therefore, more effective and better-tolerated treatment options are clearly needed. In recent years, several natural compounds (such as curcumin, epigallocatechin 3-gallate (EGCG), resveratrol, sulforaphane and Withaferin-A), characterized by long-term safety and negligible and/or inexistent side effects, have been proposed as possible adjuvants of traditional chemotherapy. Indeed, several in vitro and in vivo studies have shown that phytocompounds can effectively inhibit tumor cell proliferation, stimulate autophagy, induce apoptosis, and specifically target ovarian cancer stem cells (CSCs), which are generally considered to be responsible for tumor recurrence in several types of cancer. Here we review current literature on the role of natural products in ovarian cancer chemoprevention, highlighting their effects particularly on the regulation of inflammation, autophagy, proliferation and apoptosis, chemotherapy resistance, and ovarian CSC growth. date: 2017 date_type: published publication: Cancer Letters volume: 411 pagerange: 191-200 pages: 0 id_number: doi:10.1016/j.canlet.2017.09.050 refereed: TRUE issn: 0304-3835 official_url: http://doi.org/10.1016/j.canlet.2017.09.050 num_pieces: 0 gscholar_impact: 0 gscholar_datestamp: 0000-00-00 00:00:00 access: close language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Cerrado Inglés Among gynaecological cancers, ovarian cancer represents the leading cause of death in women. Current treatment for ovarian cancer entails surgery followed by combined chemotherapy with platinum and taxane, which are associated, particularly cisplatin, with severe side effects. While this treatment approach appears to be initially effective in a high number of patients, nearly 70% of them suffer a relapse within a few months after initial treatment. Therefore, more effective and better-tolerated treatment options are clearly needed. In recent years, several natural compounds (such as curcumin, epigallocatechin 3-gallate (EGCG), resveratrol, sulforaphane and Withaferin-A), characterized by long-term safety and negligible and/or inexistent side effects, have been proposed as possible adjuvants of traditional chemotherapy. Indeed, several in vitro and in vivo studies have shown that phytocompounds can effectively inhibit tumor cell proliferation, stimulate autophagy, induce apoptosis, and specifically target ovarian cancer stem cells (CSCs), which are generally considered to be responsible for tumor recurrence in several types of cancer. Here we review current literature on the role of natural products in ovarian cancer chemoprevention, highlighting their effects particularly on the regulation of inflammation, autophagy, proliferation and apoptosis, chemotherapy resistance, and ovarian CSC growth. metadata Pistollato, Francesca; Calderón Iglesias, Rubén; Ruiz Salces, Roberto; Aparicio Obregón, Silvia; Crespo Alvare, Jorge; Dzul Lopez, Luis; Giampieri, Francesca y Battino, Maurizio mail SIN ESPECIFICAR, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, luis.dzul@unini.edu.mx, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) The use of natural compounds for the targeting and chemoprevention of ovarian cancer. Cancer Letters, 411. pp. 191-200. ISSN 0304-3835