eprintid: 14366 rev_number: 9 eprint_status: archive userid: 2 dir: disk0/00/01/43/66 datestamp: 2024-09-24 23:30:13 lastmod: 2024-09-24 23:30:14 status_changed: 2024-09-24 23:30:13 type: article metadata_visibility: show creators_name: Godos, Justyna creators_name: Romano, Giovanni Luca creators_name: Laudani, Samuele creators_name: Gozzo, Lucia creators_name: Guerrera, Ida creators_name: Dominguez Azpíroz, Irma creators_name: Martínez Díaz, Raquel creators_name: Quiles, José L. creators_name: Battino, Maurizio creators_name: Drago, Filippo creators_name: Giampieri, Francesca creators_name: Galvano, Fabio creators_name: Grosso, Giuseppe creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: irma.dominguez@unini.edu.mx creators_id: raquel.martinez@uneatlantico.es creators_id: jose.quiles@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es creators_id: creators_id: francesca.giampieri@uneatlantico.es creators_id: creators_id: title: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action ispublished: pub subjects: uneat_bm subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: uninipr_produccion_cientifica divisions: unic_produccion_cientifica divisions: uniromana_produccion_cientifica full_text_status: public keywords: flavan-3-ols; polyphenols; inflammation; vascular; gut microbiota abstract: Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota. date: 2024-07 publication: Nutrients volume: 16 number: 15 pagerange: 2471 id_number: doi:10.3390/nu16152471 refereed: TRUE issn: 2072-6643 official_url: http://doi.org/10.3390/nu16152471 access: open language: en citation: Artículo Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Universidad Internacional do Cuanza > Investigación > Producción Científica Universidad de La Romana > Investigación > Producción Científica Abierto Inglés Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota. metadata Godos, Justyna; Romano, Giovanni Luca; Laudani, Samuele; Gozzo, Lucia; Guerrera, Ida; Dominguez Azpíroz, Irma; Martínez Díaz, Raquel; Quiles, José L.; Battino, Maurizio; Drago, Filippo; Giampieri, Francesca; Galvano, Fabio y Grosso, Giuseppe mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, irma.dominguez@unini.edu.mx, raquel.martinez@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action. Nutrients, 16 (15). p. 2471. ISSN 2072-6643 document_url: http://repositorio.uneatlantico.es/id/eprint/14366/1/nutrients-16-02471.pdf