eprintid: 14342 rev_number: 9 eprint_status: archive userid: 2 dir: disk0/00/01/43/42 datestamp: 2024-09-23 23:30:14 lastmod: 2024-09-23 23:30:15 status_changed: 2024-09-23 23:30:14 type: article metadata_visibility: show creators_name: Khawaja, Seher Ansar creators_name: Farooq, Muhammad Shoaib creators_name: Ishaq, Kashif creators_name: Alsubaie, Najah creators_name: Karamti, Hanen creators_name: Caro Montero, Elizabeth creators_name: Silva Alvarado, Eduardo René creators_name: Ashraf, Imran creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: elizabeth.caro@uneatlantico.es creators_id: eduardo.silva@funiber.org creators_id: title: Prediction of leukemia peptides using convolutional neural network and protein compositions ispublished: pub subjects: uneat_bm subjects: uneat_eng divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: uninipr_produccion_cientifica divisions: unic_produccion_cientifica divisions: uniromana_produccion_cientifica full_text_status: public keywords: Leukemia detection; Protein sequences; Deep learning; Convolutional neural network abstract: Leukemia is a type of blood cell cancer that is in the bone marrow’s blood-forming cells. Two types of Leukemia are acute and chronic; acute enhances fast and chronic growth gradually which are further classified into lymphocytic and myeloid leukemias. This work evaluates a unique deep convolutional neural network (CNN) classifier that improves identification precision by carefully examining concatenated peptide patterns. The study uses leukemia protein expression for experiments supporting two different techniques including independence and applied cross-validation. In addition to CNN, multilayer perceptron (MLP), gated recurrent unit (GRU), and recurrent neural network (RNN) are applied. The experimental results show that the CNN model surpasses competitors with its outstanding predictability in independent and cross-validation testing applied on different features extracted from protein expressions such as amino acid composition (AAC) with a group of AAC (GAAC), tripeptide composition (TPC) with a group of TPC (GTPC), and dipeptide composition (DPC) for calculating its accuracies with their receiver operating characteristic (ROC) curve. In independence testing, a feature expression of AAC and a group of GAAC are applied using MLP and CNN modules, and ROC curves are achieved with overall 100% accuracy for the detection of protein patterns. In cross-validation testing, a feature expression on a group of AAC and GAAC patterns achieved 98.33% accuracy which is the highest for the CNN module. Furthermore, ROC curves show a 0.965% extraordinary result for the GRU module. The findings show that the CNN model is excellent at figuring out leukemia illnesses from protein expressions with higher accuracy. date: 2024 publication: BMC Cancer volume: 24 number: 1 id_number: doi:10.1186/s12885-024-12609-8 refereed: TRUE issn: 1471-2407 official_url: http://doi.org/10.1186/s12885-024-12609-8 access: close language: en citation: Artículo Materias > Biomedicina Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Universidad Internacional do Cuanza > Investigación > Producción Científica Universidad de La Romana > Investigación > Producción Científica Cerrado Inglés Leukemia is a type of blood cell cancer that is in the bone marrow’s blood-forming cells. Two types of Leukemia are acute and chronic; acute enhances fast and chronic growth gradually which are further classified into lymphocytic and myeloid leukemias. This work evaluates a unique deep convolutional neural network (CNN) classifier that improves identification precision by carefully examining concatenated peptide patterns. The study uses leukemia protein expression for experiments supporting two different techniques including independence and applied cross-validation. In addition to CNN, multilayer perceptron (MLP), gated recurrent unit (GRU), and recurrent neural network (RNN) are applied. The experimental results show that the CNN model surpasses competitors with its outstanding predictability in independent and cross-validation testing applied on different features extracted from protein expressions such as amino acid composition (AAC) with a group of AAC (GAAC), tripeptide composition (TPC) with a group of TPC (GTPC), and dipeptide composition (DPC) for calculating its accuracies with their receiver operating characteristic (ROC) curve. In independence testing, a feature expression of AAC and a group of GAAC are applied using MLP and CNN modules, and ROC curves are achieved with overall 100% accuracy for the detection of protein patterns. In cross-validation testing, a feature expression on a group of AAC and GAAC patterns achieved 98.33% accuracy which is the highest for the CNN module. Furthermore, ROC curves show a 0.965% extraordinary result for the GRU module. The findings show that the CNN model is excellent at figuring out leukemia illnesses from protein expressions with higher accuracy. metadata Khawaja, Seher Ansar; Farooq, Muhammad Shoaib; Ishaq, Kashif; Alsubaie, Najah; Karamti, Hanen; Caro Montero, Elizabeth; Silva Alvarado, Eduardo René y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, elizabeth.caro@uneatlantico.es, eduardo.silva@funiber.org, SIN ESPECIFICAR (2024) Prediction of leukemia peptides using convolutional neural network and protein compositions. BMC Cancer, 24 (1). ISSN 1471-2407 document_url: http://repositorio.uneatlantico.es/id/eprint/14342/1/s12885-024-12609-8.pdf