TY  - JOUR
N2  - Background
Cognitive impairment is projected to affect a preponderant proportion of the aging population. Lifelong dietary habits have been hypothesized to play a role in preventing cognitive decline. Among the most studied dietary components, fish consumptionhas been extensively studied for its potential effects on the human brain.

Aims
To perform a meta-analysis of observational studies exploring the association between fish intake and cognitive impairment/decline and all types of dementia.

Methods
A systematic search of electronic databases was performed to identify observational studies providing quantitative data on fish consumption and outcomes of interest. Random effects models for meta-analyses using only extreme exposure categories, subgroup analyses, and dose-response analyses were performed to estimate cumulative risk ratios (RRs) and 95% confidence intervals (CIs).

Results
The meta-analysis comprised 35 studies. Individuals reporting the highest vs. the lowest fish consumption were associated with a lower likelihood of cognitive impairment/decline (RR?=?0.82, 95% CI: 0.75, 0.90, I2?=?61.1%), dementia (RR?=?0.82, 95% CI: 0.73, 0.93, I2?=?38.7%), and Alzheimer?s disease (RR?=?0.80, 95% CI: 0.67, 0.96, I2?=?20.3%). The dose-response relation revealed a significantly decreased risk of cognitive impairment/decline and all cognitive outcomes across higher levels of fish intake up to 30% for 150 g/d (RR?=?0.70, 95% CI: 0.52, 0.95). The results of this relation based on APOE ?4 allele status was mixed based on the outcome investigated.

Conclusions
Current findings suggest fish consumption is associated with a lower risk of cognitive impairment/decline in a dose-response manner, while for dementia and Alzheimer?s disease there is a need for further studies to improve the strength of evidence.
TI  - Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies
Y1  - 2024/08//
JF  - Aging Clinical and Experimental Research
AV  - public
ID  - uneatlantico14336
IS  - 1
VL  - 36
KW  - Fish; Dementia; Cognitive status; Alzheimer?s disease; Meta-analysis
A1  - Godos, Justyna
A1  - Micek, Agnieszka
A1  - Currenti, Walter
A1  - Franchi, Carlotta
A1  - Poli, Andrea
A1  - Battino, Maurizio
A1  - Dolci, Alberto
A1  - Ricci, Cristian
A1  - Ungvari, Zoltan
A1  - Grosso, Giuseppe
UR  - http://doi.org/10.1007/s40520-024-02823-6
SN  - 1720-8319
ER  -