%0 Journal Article
%@ 1720-8319
%A Godos, Justyna
%A Micek, Agnieszka
%A Currenti, Walter
%A Franchi, Carlotta
%A Poli, Andrea
%A Battino, Maurizio
%A Dolci, Alberto
%A Ricci, Cristian
%A Ungvari, Zoltan
%A Grosso, Giuseppe
%D 2024
%F uneatlantico:14336
%J Aging Clinical and Experimental Research
%K Fish; Dementia; Cognitive status; Alzheimer’s disease; Meta-analysis
%N 1
%T Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies
%U http://repositorio.uneatlantico.es/id/eprint/14336/
%V 36
%X Background Cognitive impairment is projected to affect a preponderant proportion of the aging population. Lifelong dietary habits have been hypothesized to play a role in preventing cognitive decline. Among the most studied dietary components, fish consumptionhas been extensively studied for its potential effects on the human brain.  Aims To perform a meta-analysis of observational studies exploring the association between fish intake and cognitive impairment/decline and all types of dementia.  Methods A systematic search of electronic databases was performed to identify observational studies providing quantitative data on fish consumption and outcomes of interest. Random effects models for meta-analyses using only extreme exposure categories, subgroup analyses, and dose-response analyses were performed to estimate cumulative risk ratios (RRs) and 95% confidence intervals (CIs).  Results The meta-analysis comprised 35 studies. Individuals reporting the highest vs. the lowest fish consumption were associated with a lower likelihood of cognitive impairment/decline (RR = 0.82, 95% CI: 0.75, 0.90, I2 = 61.1%), dementia (RR = 0.82, 95% CI: 0.73, 0.93, I2 = 38.7%), and Alzheimer’s disease (RR = 0.80, 95% CI: 0.67, 0.96, I2 = 20.3%). The dose-response relation revealed a significantly decreased risk of cognitive impairment/decline and all cognitive outcomes across higher levels of fish intake up to 30% for 150 g/d (RR = 0.70, 95% CI: 0.52, 0.95). The results of this relation based on APOE ε4 allele status was mixed based on the outcome investigated.  Conclusions Current findings suggest fish consumption is associated with a lower risk of cognitive impairment/decline in a dose-response manner, while for dementia and Alzheimer’s disease there is a need for further studies to improve the strength of evidence.