@article{uneatlantico14336,
         journal = {Aging Clinical and Experimental Research},
           month = {Agosto},
          volume = {36},
          number = {1},
           title = {Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies},
            year = {2024},
          author = {Justyna Godos and Agnieszka Micek and Walter Currenti and Carlotta Franchi and Andrea Poli and Maurizio Battino and Alberto Dolci and Cristian Ricci and Zoltan Ungvari and Giuseppe Grosso},
        keywords = {Fish; Dementia; Cognitive status; Alzheimer?s disease; Meta-analysis},
             url = {http://repositorio.uneatlantico.es/id/eprint/14336/},
        abstract = {Background
Cognitive impairment is projected to affect a preponderant proportion of the aging population. Lifelong dietary habits have been hypothesized to play a role in preventing cognitive decline. Among the most studied dietary components, fish consumptionhas been extensively studied for its potential effects on the human brain.

Aims
To perform a meta-analysis of observational studies exploring the association between fish intake and cognitive impairment/decline and all types of dementia.

Methods
A systematic search of electronic databases was performed to identify observational studies providing quantitative data on fish consumption and outcomes of interest. Random effects models for meta-analyses using only extreme exposure categories, subgroup analyses, and dose-response analyses were performed to estimate cumulative risk ratios (RRs) and 95\% confidence intervals (CIs).

Results
The meta-analysis comprised 35 studies. Individuals reporting the highest vs. the lowest fish consumption were associated with a lower likelihood of cognitive impairment/decline (RR = 0.82, 95\% CI: 0.75, 0.90, I2 = 61.1\%), dementia (RR = 0.82, 95\% CI: 0.73, 0.93, I2 = 38.7\%), and Alzheimer?s disease (RR = 0.80, 95\% CI: 0.67, 0.96, I2 = 20.3\%). The dose-response relation revealed a significantly decreased risk of cognitive impairment/decline and all cognitive outcomes across higher levels of fish intake up to 30\% for 150 g/d (RR = 0.70, 95\% CI: 0.52, 0.95). The results of this relation based on APOE {\ensuremath{\epsilon}}4 allele status was mixed based on the outcome investigated.

Conclusions
Current findings suggest fish consumption is associated with a lower risk of cognitive impairment/decline in a dose-response manner, while for dementia and Alzheimer?s disease there is a need for further studies to improve the strength of evidence.}
}