eprintid: 14209 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/01/42/09 datestamp: 2024-09-16 23:30:13 lastmod: 2024-09-18 23:30:10 status_changed: 2024-09-16 23:30:13 type: article metadata_visibility: show creators_name: Hiensch, Anouk E. creators_name: Depenbusch, Johanna creators_name: Schmidt, Martina E. creators_name: Monninkhof, Evelyn M. creators_name: Peláez, Mireia creators_name: Clauss, Dorothea creators_name: Gunasekara, Nadira creators_name: Zimmer, Philipp creators_name: Belloso, Jon creators_name: Trevaskis, Mark creators_name: Rundqvist, Helene creators_name: Wiskemann, Joachim creators_name: Müller, Jana creators_name: Sweegers, Maike G. creators_name: Fremd, Carlo creators_name: Altena, Renske creators_name: Gorecki, Maciej creators_name: Bijlsma, Rhodé creators_name: van Leeuwen-Snoeks, Lobke creators_name: ten Bokkel Huinink, Daan creators_name: Sonke, Gabe creators_name: Lahuerta, Ainhara creators_name: Mann, G. Bruce creators_name: Francis, Prudence A. creators_name: Richardson, Gary creators_name: Malter, Wolfram creators_name: van der Wall, Elsken creators_name: Aaronson, Neil K. creators_name: Senkus, Elzbieta creators_name: Urruticoechea, Ander creators_name: Zopf, Eva M. creators_name: Bloch, Wilhelm creators_name: Stuiver, Martijn M. creators_name: Wengstrom, Yvonne creators_name: Steindorf, Karen creators_name: May, Anne M. creators_id: creators_id: creators_id: creators_id: creators_id: mireia.pelaez@uneatlantico.es creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: title: Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial ispublished: pub subjects: uneat_bm subjects: uneat_dp divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: Breast cancer ; Outcomes research abstract: Physical exercise both during and after curative cancer treatment has been shown to reduce side effects. Evidence in the metastatic cancer setting is scarce, and interventions that improve health-related quality of life (HRQOL) are much needed for patients with metastatic breast cancer (MBC). The multinational randomized controlled PREFERABLE-EFFECT trial assessed the effects of exercise on fatigue and HRQOL in patients with MBC. In total, 357 patients with MBC and a life expectancy of ≥6 months but without unstable bone metastases were recruited at eight study centers across five European countries and Australia. Participants were randomly assigned (1:1) to usual care (control group, n = 179) or a 9-month supervised exercise program (exercise group, n = 178). Intervention effects on physical fatigue (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-FA12 scale) and HRQOL (EORTC QLQ-C30 summary score) were determined by comparing the change from baseline to 3, 6 (primary timepoint) and 9 months between groups using mixed models for repeated measures, adjusted for baseline values of the outcome, line of treatment (first or second versus third or higher) and study center. Exercise resulted in significant positive effects on both primary outcomes. Physical fatigue was significantly lower (−5.3 (95% confidence interval (CI), −10.0 to −0.6), Bonferroni–Holm-adjusted P = 0.027; Cohen's effect size, 0.22) and HRQOL significantly higher (4.8 (95% CI, 2.2–7.4), Bonferroni–Holm-adjusted P = 0.0003; effect size, 0.33) in the exercise group than in the control group at 6 months. Two serious adverse events occurred (that is, fractures), but both were not related to bone metastases. These results demonstrate that supervised exercise has positive effects on physical fatigue and HRQOL in patients with MBC and should be recommended as part of supportive care. date: 2024 publication: Nature Medicine id_number: doi:10.1038/s41591-024-03143-y refereed: TRUE issn: 1078-8956 official_url: http://doi.org/10.1038/s41591-024-03143-y access: open language: en citation: Artículo Materias > Biomedicina Materias > Educación física y el deporte Universidad Europea del Atlántico > Investigación > Artículos y libros Abierto Inglés Physical exercise both during and after curative cancer treatment has been shown to reduce side effects. Evidence in the metastatic cancer setting is scarce, and interventions that improve health-related quality of life (HRQOL) are much needed for patients with metastatic breast cancer (MBC). The multinational randomized controlled PREFERABLE-EFFECT trial assessed the effects of exercise on fatigue and HRQOL in patients with MBC. In total, 357 patients with MBC and a life expectancy of ≥6 months but without unstable bone metastases were recruited at eight study centers across five European countries and Australia. Participants were randomly assigned (1:1) to usual care (control group, n = 179) or a 9-month supervised exercise program (exercise group, n = 178). Intervention effects on physical fatigue (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-FA12 scale) and HRQOL (EORTC QLQ-C30 summary score) were determined by comparing the change from baseline to 3, 6 (primary timepoint) and 9 months between groups using mixed models for repeated measures, adjusted for baseline values of the outcome, line of treatment (first or second versus third or higher) and study center. Exercise resulted in significant positive effects on both primary outcomes. Physical fatigue was significantly lower (−5.3 (95% confidence interval (CI), −10.0 to −0.6), Bonferroni–Holm-adjusted P = 0.027; Cohen's effect size, 0.22) and HRQOL significantly higher (4.8 (95% CI, 2.2–7.4), Bonferroni–Holm-adjusted P = 0.0003; effect size, 0.33) in the exercise group than in the control group at 6 months. Two serious adverse events occurred (that is, fractures), but both were not related to bone metastases. These results demonstrate that supervised exercise has positive effects on physical fatigue and HRQOL in patients with MBC and should be recommended as part of supportive care. metadata Hiensch, Anouk E.; Depenbusch, Johanna; Schmidt, Martina E.; Monninkhof, Evelyn M.; Peláez, Mireia; Clauss, Dorothea; Gunasekara, Nadira; Zimmer, Philipp; Belloso, Jon; Trevaskis, Mark; Rundqvist, Helene; Wiskemann, Joachim; Müller, Jana; Sweegers, Maike G.; Fremd, Carlo; Altena, Renske; Gorecki, Maciej; Bijlsma, Rhodé; van Leeuwen-Snoeks, Lobke; ten Bokkel Huinink, Daan; Sonke, Gabe; Lahuerta, Ainhara; Mann, G. Bruce; Francis, Prudence A.; Richardson, Gary; Malter, Wolfram; van der Wall, Elsken; Aaronson, Neil K.; Senkus, Elzbieta; Urruticoechea, Ander; Zopf, Eva M.; Bloch, Wilhelm; Stuiver, Martijn M.; Wengstrom, Yvonne; Steindorf, Karen y May, Anne M. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, mireia.pelaez@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial. Nature Medicine. ISSN 1078-8956 document_url: http://repositorio.uneatlantico.es/id/eprint/14209/1/s41591-024-03143-y.pdf