TY  - JOUR
A1  - Hiensch, Anouk E.
A1  - Depenbusch, Johanna
A1  - Schmidt, Martina E.
A1  - Monninkhof, Evelyn M.
A1  - Peláez, Mireia
A1  - Clauss, Dorothea
A1  - Gunasekara, Nadira
A1  - Zimmer, Philipp
A1  - Belloso, Jon
A1  - Trevaskis, Mark
A1  - Rundqvist, Helene
A1  - Wiskemann, Joachim
A1  - Müller, Jana
A1  - Sweegers, Maike G.
A1  - Fremd, Carlo
A1  - Altena, Renske
A1  - Gorecki, Maciej
A1  - Bijlsma, Rhodé
A1  - van Leeuwen-Snoeks, Lobke
A1  - ten Bokkel Huinink, Daan
A1  - Sonke, Gabe
A1  - Lahuerta, Ainhara
A1  - Mann, G. Bruce
A1  - Francis, Prudence A.
A1  - Richardson, Gary
A1  - Malter, Wolfram
A1  - van der Wall, Elsken
A1  - Aaronson, Neil K.
A1  - Senkus, Elzbieta
A1  - Urruticoechea, Ander
A1  - Zopf, Eva M.
A1  - Bloch, Wilhelm
A1  - Stuiver, Martijn M.
A1  - Wengstrom, Yvonne
A1  - Steindorf, Karen
A1  - May, Anne M.
KW  - Breast cancer ; Outcomes research
UR  - http://doi.org/10.1038/s41591-024-03143-y
SN  - 1078-8956
N2  - Physical exercise both during and after curative cancer treatment has been shown to reduce side effects. Evidence in the metastatic cancer setting is scarce, and interventions that improve health-related quality of life (HRQOL) are much needed for patients with metastatic breast cancer (MBC). The multinational randomized controlled PREFERABLE-EFFECT trial assessed the effects of exercise on fatigue and HRQOL in patients with MBC. In total, 357 patients with MBC and a life expectancy of ?6?months but without unstable bone metastases were recruited at eight study centers across five European countries and Australia. Participants were randomly assigned (1:1) to usual care (control group, n?=?179) or a 9-month supervised exercise program (exercise group, n?=?178). Intervention effects on physical fatigue (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-FA12 scale) and HRQOL (EORTC QLQ-C30 summary score) were determined by comparing the change from baseline to 3, 6 (primary timepoint) and 9?months between groups using mixed models for repeated measures, adjusted for baseline values of the outcome, line of treatment (first or second versus third or higher) and study center. Exercise resulted in significant positive effects on both primary outcomes. Physical fatigue was significantly lower (?5.3 (95% confidence interval (CI), ?10.0 to ?0.6), Bonferroni?Holm-adjusted P?=?0.027; Cohen's effect size, 0.22) and HRQOL significantly higher (4.8 (95% CI, 2.2?7.4), Bonferroni?Holm-adjusted P?=?0.0003; effect size, 0.33) in the exercise group than in the control group at 6?months. Two serious adverse events occurred (that is, fractures), but both were not related to bone metastases. These results demonstrate that supervised exercise has positive effects on physical fatigue and HRQOL in patients with MBC and should be recommended as part of supportive care.
TI  - Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial
Y1  - 2024///
JF  - Nature Medicine
AV  - public
ID  - uneatlantico14209
ER  -