TY  - JOUR
VL  - 112
UR  - http://doi.org/10.1016/j.fct.2017.12.041
SN  - 0278-6915
Y1  - 2018///
N2  - During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 and MUD 2 on liver hepatocellular carcinoma. Our results showed that MUD 1 presented the highest (P?<?.05) fiber, protein, carbohydrate, polyphenol and flavonoid concentration, as well as the highest (P?<?.05) total antioxidant capacity than the MUD 2 samples. MUD1 exerted also anticancer activity on HepG2 cells, by reducing cellular viability, increasing intracellular ROS levels and affecting mitochondrial functionality in a dose-dependent manner. We showed for the first time that by-products from beeswax recycling process can represent a rich source of phytochemicals with high total antioxidant capacity and anticancer activity; however, further researches are necessary to evaluate their potentiality for human health by in vivo studies.
JF  - Food and Chemical Toxicology
SP  - 126
AV  - none
A1  - Giampieri, Francesca
A1  - Quiles, José L.
A1  - Orantes-Bermejo, Francisco J.
A1  - Gasparrini, Massimiliano
A1  - Forbes-Hernandez, Tamara Y.
A1  - Sánchez-González, Cristina
A1  - Llopis, Juan
A1  - Rivas-García, Lorenzo
A1  - Afrin, Sadia
A1  - Varela-López, Alfonso
A1  - Cianciosi, Danila
A1  - Reboredo-Rodriguez, Patricia
A1  - Fernández-Piñar, Cristina Torres
A1  - Caderón Iglesia, Rubén
A1  - Ruiz Salces, Roberto
A1  - Aparicio Obregón, Silvia
A1  - Crespo-Álvarez, Jorge
A1  - Dzul Lopez, Luis
A1  - Xiao, Jianbo
A1  - Battino, Maurizio
KW  - Honey; Beeswax; Food waste; Recycling process; Chemical and phytochemical composition; Biological properties.
TI  - Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties?
EP  - 133
ID  - uneatlantico131
ER  -