eprintid: 13001 rev_number: 7 eprint_status: archive userid: 2 dir: disk0/00/01/30/01 datestamp: 2024-07-02 23:30:09 lastmod: 2024-07-02 23:30:09 status_changed: 2024-07-02 23:30:09 type: article metadata_visibility: show creators_name: García-Martínez, María creators_name: Pozueta-Cantudo, Ana creators_name: Lage, Carmen creators_name: Martínez-Dubarbie, Francisco creators_name: López-García, Sara creators_name: Fernández-Matarrubia, Marta creators_name: Corrales Pardo, Andrea creators_name: Bravo, María creators_name: Cavada, Nadia C. creators_name: Anuarbe, Pedro creators_name: Infante, Jon creators_name: López-Higuera, José Miguel creators_name: Rodríguez-Cobo, Luis creators_name: Rodríguez-Rodríguez, Eloy creators_name: Butler, Christopher R. creators_name: Sánchez-Juan, Pascual creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: andrea.corrales@uneatlantico.es creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: title: LAM Test: A New Cognitive Marker for Early Detection in Preclinical Alzheimer’s Disease ispublished: pub subjects: uneat_bm subjects: uneat_ps divisions: uneatlantico_produccion_cientifica full_text_status: none keywords: Alzheimer’s disease, associative memory, cognitive markers, early detection, long-term forgetting, neuropsychological assessment, preclinical Alzheimer’s disease abstract: Background:With the arrival of disease-modifying treatments, it is mandatory to find new cognitive markers that are sensitive to Alzheimer’s disease (AD) pathology in preclinical stages. Objective:To determine the utility of a newly developed Learning and Associative Memory face test: LAM test. This study examined the relationship between AD cerebrospinal fluid (CSF) biomarkers and performance on LAM test, and assessed its potential clinical applicability to detect subtle changes in cognitively healthy subjects at risk for AD. Methods:We studied eighty cognitively healthy volunteers from the Valdecilla cohort. 61% were women and the mean age was 67.34 years (±6.416). All participants underwent a lumbar puncture for determination of CSF biomarkers and an extensive neuropsychological assessment, including performance on learning and associative memory indices of the LAM-test after 30 min and after 1 week, and two classic word lists to assess verbal episodic memory: the Rey Auditory Verbal Learning Test (RAVLT) and the Free and Cued Selective Reminding Test (FCSRT). We analyzed cognitive performance according to amyloid status (A+ versus A–) and to ATN model (A–T–N–; A+T–N–; A+T+N–/A+T+N+). Results:Performance on the LAM-test was significantly correlated with CSF Aβ ratio. A+ participants performed worse on both learning (mean difference = 2.19, p = 0.002) and memory LAM measures than A– (mean difference = 2.19, p = 0.004). A decline in performance was observed along the Alzheimer’s continuum, with significant differences between ATN groups. Conclusions:Our findings suggest that LAM test could be a useful tool for the early detection of subjects within the AD continuum, outperforming classical memory tests. date: 2024-06 publication: Journal of Alzheimer's Disease pagerange: 1-15 id_number: doi:10.3233/JAD-240067 refereed: TRUE issn: 13872877 official_url: http://doi.org/10.3233/JAD-240067 access: close language: en citation: Artículo Materias > Biomedicina Materias > Psicología Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Background:With the arrival of disease-modifying treatments, it is mandatory to find new cognitive markers that are sensitive to Alzheimer’s disease (AD) pathology in preclinical stages. Objective:To determine the utility of a newly developed Learning and Associative Memory face test: LAM test. This study examined the relationship between AD cerebrospinal fluid (CSF) biomarkers and performance on LAM test, and assessed its potential clinical applicability to detect subtle changes in cognitively healthy subjects at risk for AD. Methods:We studied eighty cognitively healthy volunteers from the Valdecilla cohort. 61% were women and the mean age was 67.34 years (±6.416). All participants underwent a lumbar puncture for determination of CSF biomarkers and an extensive neuropsychological assessment, including performance on learning and associative memory indices of the LAM-test after 30 min and after 1 week, and two classic word lists to assess verbal episodic memory: the Rey Auditory Verbal Learning Test (RAVLT) and the Free and Cued Selective Reminding Test (FCSRT). We analyzed cognitive performance according to amyloid status (A+ versus A–) and to ATN model (A–T–N–; A+T–N–; A+T+N–/A+T+N+). Results:Performance on the LAM-test was significantly correlated with CSF Aβ ratio. A+ participants performed worse on both learning (mean difference = 2.19, p = 0.002) and memory LAM measures than A– (mean difference = 2.19, p = 0.004). A decline in performance was observed along the Alzheimer’s continuum, with significant differences between ATN groups. Conclusions:Our findings suggest that LAM test could be a useful tool for the early detection of subjects within the AD continuum, outperforming classical memory tests. metadata García-Martínez, María; Pozueta-Cantudo, Ana; Lage, Carmen; Martínez-Dubarbie, Francisco; López-García, Sara; Fernández-Matarrubia, Marta; Corrales Pardo, Andrea; Bravo, María; Cavada, Nadia C.; Anuarbe, Pedro; Infante, Jon; López-Higuera, José Miguel; Rodríguez-Cobo, Luis; Rodríguez-Rodríguez, Eloy; Butler, Christopher R. y Sánchez-Juan, Pascual mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, andrea.corrales@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) LAM Test: A New Cognitive Marker for Early Detection in Preclinical Alzheimer’s Disease. Journal of Alzheimer's Disease. pp. 1-15. ISSN 13872877