eprintid: 128 rev_number: 10 eprint_status: archive userid: 2 importid: 0 dir: disk0/00/00/01/28 datestamp: 2021-06-01 23:55:11 lastmod: 2023-06-30 23:30:18 status_changed: 2021-06-01 23:55:11 type: article succeeds: 0 commentary: 0 metadata_visibility: show item_issues_count: 0 sword_depositor: 0 creators_name: Sánchez-Díaz, María creators_name: Nicolás-Ávila, José Ángel creators_name: Cordero, Mario D. creators_name: Hidalgo, Andrés creators_id: creators_id: creators_id: mario.cordero@uneatlantico.es creators_id: title: Mitochondrial Adaptations in the Growing Heart ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica full_text_status: none abstract: The heart pumps blood throughout the whole life of an organism, without rest periods during which to replenish energy or detoxify. Hence, cardiomyocytes, the working units of the heart, have mechanisms to ensure constitutive production of energy and detoxification to preserve fitness and function for decades. Even more challenging, the heart must adapt to the varying conditions of the organism from fetal life to adulthood, old age, and pathological stress. Mitochondria are at the nexus of these processes by producing not only energy but also metabolites and oxidative byproducts that can activate alarm signals and be toxic to the cell. We review basic concepts about cardiac mitochondria with a focus on their remarkable adaptations, including elimination, throughout the mammalian lifetime. date: 2020-02 date_type: published publication: Trends in Endocrinology & Metabolism volume: 31 number: 4 pagerange: 308-319 pages: 0 id_number: doi:10.1016/j.tem.2020.01.006 refereed: TRUE issn: 1043-2760 official_url: http://doi.org/10.1016/j.tem.2020.01.006 num_pieces: 0 gscholar_impact: 0 gscholar_datestamp: 0000-00-00 00:00:00 access: close language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Cerrado Inglés The heart pumps blood throughout the whole life of an organism, without rest periods during which to replenish energy or detoxify. Hence, cardiomyocytes, the working units of the heart, have mechanisms to ensure constitutive production of energy and detoxification to preserve fitness and function for decades. Even more challenging, the heart must adapt to the varying conditions of the organism from fetal life to adulthood, old age, and pathological stress. Mitochondria are at the nexus of these processes by producing not only energy but also metabolites and oxidative byproducts that can activate alarm signals and be toxic to the cell. We review basic concepts about cardiac mitochondria with a focus on their remarkable adaptations, including elimination, throughout the mammalian lifetime. metadata Sánchez-Díaz, María; Nicolás-Ávila, José Ángel; Cordero, Mario D. y Hidalgo, Andrés mail SIN ESPECIFICAR, SIN ESPECIFICAR, mario.cordero@uneatlantico.es, SIN ESPECIFICAR (2020) Mitochondrial Adaptations in the Growing Heart. Trends in Endocrinology & Metabolism, 31 (4). pp. 308-319. ISSN 1043-2760