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primary topic: The anti-metastatic effect of Manuka honey on colonspheres enriched with cancer stem cells: how does it influence the epithelial-mesenchymal transition process, angiogenesis, and telomere length?

The anti-metastatic effect of Manuka honey on colonspheres enriched with cancer stem cells: how does it influence the epithelial-mesenchymal transition process, angiogenesis, and telomere length?
type: AcademicArticle
type: Article
abstract: Colorectal cancer often leads to metastasis, with cancer stem cells (CSCs) playing a pivotal role in this process. Two closely linked mechanisms, epithelial-mesenchymal transition and angiogenesis, contribute to metastasis and recent research has also highlighted the impact of telomere replication on this harmful tumor progression. Standard chemotherapy alone can inadvertently promote drug-resistant CSCs, posing a challenge. Combining chemotherapy with other compounds, including natural ones, shows promise in enhancing effectiveness while minimizing side effects. This study investigated the anti-metastatic potential of Manuka honey, both alone and in combination with 5-Fluorouracil, using a 3D model of colon spheres enriched with CSCs-like cells. In summary, it was observed that the treatment reduced migration ability by increasing the expression of E-cadherin through the downregulation of transcription factors Slug, Snail, and Twist. Additionally, it downregulated pro-angiogenic factors and shortened CSC telomeres by downregulating c-Myc, demonstrating an effective anti-metastatic potential. This study suggests new research opportunities for studying the impact of natural compounds when combined with pharmaceuticals, with the potential to enhance effectiveness and reduce side effects.
date: 2024-06
is part of: Food & Function
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: Biomedicine
subject: Nutrition

Food & Function
type: Collection
issn: 20426496

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Tamara Yuliett Forbes-Hernández
type: Person
given name: Tamara Yuliett
family name: Forbes-Hernández

Yasmany Armas Diaz
type: Person
given name: Yasmany
family name: Armas Diaz

José L. Quiles
type: Person
given name: José L.
family name: Quiles

Danila Cianciosi
type: Person
given name: Danila
family name: Cianciosi

Maria Elexpuru Zabaleta
type: Person
given name: Maria
family name: Elexpuru Zabaleta

http://repositorio.uneatlantico.es/id/eprint/12748/
title: HTML Summary of #12748 The anti-metastatic effect of Manuka honey on colonspheres enriched with cancer stem cells: how does it influence the epithelial-mesenchymal transition process, angiogenesis, and telomere length?
format: text/html
primary topic: The anti-metastatic effect of Manuka honey on colonspheres enriched with cancer stem cells: how does it influence the epithelial-mesenchymal transition process, angiogenesis, and telomere length?

Biomedicine
type: Concept
preferred label: Biomedicina @es

Nutrition
type: Concept
preferred label: Alimentación @es