<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "The anti-metastatic effect of Manuka honey on colonspheres enriched with cancer stem cells: how does it influence the epithelial-mesenchymal transition process, angiogenesis, and telomere length?"^^ . "Colorectal cancer often leads to metastasis, with cancer stem cells (CSCs) playing a pivotal role in this process. Two closely linked mechanisms, epithelial-mesenchymal transition and angiogenesis, contribute to metastasis and recent research has also highlighted the impact of telomere replication on this harmful tumor progression. Standard chemotherapy alone can inadvertently promote drug-resistant CSCs, posing a challenge. Combining chemotherapy with other compounds, including natural ones, shows promise in enhancing effectiveness while minimizing side effects. This study investigated the anti-metastatic potential of Manuka honey, both alone and in combination with 5-Fluorouracil, using a 3D model of colon spheres enriched with CSCs-like cells. In summary, it was observed that the treatment reduced migration ability by increasing the expression of E-cadherin through the downregulation of transcription factors Slug, Snail, and Twist. Additionally, it downregulated pro-angiogenic factors and shortened CSC telomeres by downregulating c-Myc, demonstrating an effective anti-metastatic potential. This study suggests new research opportunities for studying the impact of natural compounds when combined with pharmaceuticals, with the potential to enhance effectiveness and reduce side effects."^^ . "2024-06" . . . "Food & Function"^^ . . . "20426496" . . . . . . . . . . . . . . . . . . . . . . . . . "Tamara Yuliett"^^ . "Forbes-Hernández"^^ . "Tamara Yuliett Forbes-Hernández"^^ . . "Yasmany"^^ . "Armas Diaz"^^ . "Yasmany Armas Diaz"^^ . . "Francesca"^^ . "Giampieri"^^ . "Francesca Giampieri"^^ . . "Maurizio"^^ . "Battino"^^ . "Maurizio Battino"^^ . . "Danila"^^ . "Cianciosi"^^ . "Danila Cianciosi"^^ . . "José L."^^ . "Quiles"^^ . "José L. Quiles"^^ . . "Maria"^^ . "Elexpuru Zabaleta"^^ . "Maria Elexpuru Zabaleta"^^ . . . . . "HTML Summary of #12748 \n\nThe anti-metastatic effect of Manuka honey on colonspheres enriched with cancer stem cells: how does it influence the epithelial-mesenchymal transition process, angiogenesis, and telomere length?\n\n" . "text/html" . . . "Biomedicine"@en . "Biomedicina"@es . . . "Nutrition"@en . "Alimentación"@es . .