TY  - JOUR
N2  - Amid growing concerns about antibiotic resistance, innovative strategies are imperative in addressing bacterial infections in aquaculture. Quorum quenching (QQ), the enzymatic inhibition of quorum sensing (QS), has emerged as a promising solution. This study delves into the QQ capabilities of the probiotic strain Bacillus velezensis D-18 and its products, particularly in Vibrio anguillarum 507 communication and biofilm formation. Chromobacterium violaceum MK was used as a biomarker in this study, and the results confirmed that B. velezensis D-18 effectively inhibits QS. Further exploration into the QQ mechanism revealed the presence of lactonase activity by B. velezensis D-18 that degraded both long- and short-chain acyl homoserine lactones (AHLs). PCR analysis demonstrated the presence of a homologous lactonase-producing gene, ytnP, in the genome of B. velezensis D-18. The study evaluated the impact of B. velezensis D-18 on V. anguillarum 507 growth and biofilm formation. The probiotic not only controls the biofilm formation of V. anguillarum but also significantly restrains pathogen growth. Therefore, B. velezensis D-18 demonstrates substantial potential for preventing V. anguillarum diseases in aquaculture through its QQ capacity. The ability to disrupt bacterial communication and control biofilm formation positions B. velezensis D-18 as a promising eco-friendly alternative to conventional antibiotics in managing bacterial diseases in aquaculture.
UR  - http://doi.org/10.3390/microorganisms12050890
VL  - 12
Y1  - 2024/04//
TI  - An In-Depth Study on the Inhibition of Quorum Sensing by Bacillus velezensis D-18: Its Significant Impact on Vibrio Biofilm Formation in Aquaculture
ID  - uneatlantico12505
AV  - public
KW  - Bacillus; quorum sensing; quorum quenching; biofilm; Vibrio; aquaculture
IS  - 5
SN  - 2076-2607
A1  - Monzón-Atienza, Luis
A1  - Bravo, Jimena
A1  - Torrecillas, Silvia
A1  - Gómez-Mercader, Antonio
A1  - Montero, Daniel
A1  - Ramos Vivas, Jose
A1  - Galindo-Villegas, Jorge
A1  - Acosta, Félix
JF  - Microorganisms
ER  -