@article{uneatlantico12505,
          number = {5},
         journal = {Microorganisms},
           title = {An In-Depth Study on the Inhibition of Quorum Sensing by Bacillus velezensis D-18: Its Significant Impact on Vibrio Biofilm Formation in Aquaculture},
            year = {2024},
          volume = {12},
           pages = {890},
          author = {Luis Monz{\'o}n-Atienza and Jimena Bravo and Silvia Torrecillas and Antonio G{\'o}mez-Mercader and Daniel Montero and Jose Ramos Vivas and Jorge Galindo-Villegas and F{\'e}lix Acosta},
           month = {Abril},
        abstract = {Amid growing concerns about antibiotic resistance, innovative strategies are imperative in addressing bacterial infections in aquaculture. Quorum quenching (QQ), the enzymatic inhibition of quorum sensing (QS), has emerged as a promising solution. This study delves into the QQ capabilities of the probiotic strain Bacillus velezensis D-18 and its products, particularly in Vibrio anguillarum 507 communication and biofilm formation. Chromobacterium violaceum MK was used as a biomarker in this study, and the results confirmed that B. velezensis D-18 effectively inhibits QS. Further exploration into the QQ mechanism revealed the presence of lactonase activity by B. velezensis D-18 that degraded both long- and short-chain acyl homoserine lactones (AHLs). PCR analysis demonstrated the presence of a homologous lactonase-producing gene, ytnP, in the genome of B. velezensis D-18. The study evaluated the impact of B. velezensis D-18 on V. anguillarum 507 growth and biofilm formation. The probiotic not only controls the biofilm formation of V. anguillarum but also significantly restrains pathogen growth. Therefore, B. velezensis D-18 demonstrates substantial potential for preventing V. anguillarum diseases in aquaculture through its QQ capacity. The ability to disrupt bacterial communication and control biofilm formation positions B. velezensis D-18 as a promising eco-friendly alternative to conventional antibiotics in managing bacterial diseases in aquaculture.},
             url = {http://repositorio.uneatlantico.es/id/eprint/12505/},
        keywords = {Bacillus; quorum sensing; quorum quenching; biofilm; Vibrio; aquaculture}
}