eprintid: 125 rev_number: 12 eprint_status: archive userid: 2 importid: 0 dir: disk0/00/00/01/25 datestamp: 2021-06-02 23:55:05 lastmod: 2023-07-03 23:30:17 status_changed: 2021-06-02 23:55:05 type: article succeeds: 0 commentary: 0 metadata_visibility: show item_issues_count: 0 sword_depositor: 0 creators_name: Pistollato, Francesca creators_name: Forbes-Hernandez, Tamara Y. creators_name: Calderón Iglesias, Rubén creators_name: Ruiz Salces, Roberto creators_name: Elexpuru Zabaleta, Maria creators_name: Cianciosi, Danila creators_name: Giampieri, Francesca creators_name: Battino, Maurizio creators_id: francesca.pistollato@uneatlantico.es creators_id: creators_id: ruben.calderon@uneatlantico.es creators_id: roberto.ruiz@uneatlantico.es creators_id: creators_id: creators_id: creators_id: title: Pharmacological, non-pharmacological and stem cell therapies for the management of autism spectrum disorders: A focus on human studies ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica full_text_status: none keywords: Autism spectrum disorder; Pharmacological interventions; Non-Pharmacological strategies; Stem cell therapies; Dietary supplementations; Exclusion diets. abstract: In the last decade, the prevalence of autism spectrum disorders (ASD) has dramatically escalated worldwide. Currently available drugs mainly target some co-occurring symptoms of ASD, but are not effective on the core symptoms, namely impairments in communication and social interaction, and the presence of restricted and repetitive behaviors. On the other hand, transplantation of hematopoietic and mesenchymal stem cells in ASD children has been shown promising to stimulate the recruitment, proliferation, and differentiation of tissue-residing native stem cells, reducing inflammation, and improving some ASD symptoms. Moreover, several comorbidities have also been associated with ASD, such as immune dysregulation, gastrointestinal issues and gut microbiota dysbiosis. Non-pharmacological approaches, such as dietary supplementations with certain vitamins, omega-3 polyunsaturated fatty acids, probiotics, some phytochemicals (e.g., luteolin and sulforaphane), or overall diet interventions (e.g., gluten free and casein free diets) have been considered for the reduction of such comorbidities and the management of ASD. Here, interventional studies describing pharmacological and non-pharmacological treatments in ASD children and adolescents, along with stem cell-based therapies, are reviewed. date: 2020-02 date_type: published publication: Pharmacological Research volume: 152 pagerange: 104579 pages: 0 id_number: doi:10.1016/j.phrs.2019.104579 refereed: TRUE issn: 1043-6618 official_url: http://doi.org/10.1016/j.phrs.2019.104579 num_pieces: 0 gscholar_impact: 0 gscholar_datestamp: 0000-00-00 00:00:00 access: close language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Cerrado Inglés In the last decade, the prevalence of autism spectrum disorders (ASD) has dramatically escalated worldwide. Currently available drugs mainly target some co-occurring symptoms of ASD, but are not effective on the core symptoms, namely impairments in communication and social interaction, and the presence of restricted and repetitive behaviors. On the other hand, transplantation of hematopoietic and mesenchymal stem cells in ASD children has been shown promising to stimulate the recruitment, proliferation, and differentiation of tissue-residing native stem cells, reducing inflammation, and improving some ASD symptoms. Moreover, several comorbidities have also been associated with ASD, such as immune dysregulation, gastrointestinal issues and gut microbiota dysbiosis. Non-pharmacological approaches, such as dietary supplementations with certain vitamins, omega-3 polyunsaturated fatty acids, probiotics, some phytochemicals (e.g., luteolin and sulforaphane), or overall diet interventions (e.g., gluten free and casein free diets) have been considered for the reduction of such comorbidities and the management of ASD. Here, interventional studies describing pharmacological and non-pharmacological treatments in ASD children and adolescents, along with stem cell-based therapies, are reviewed. metadata Pistollato, Francesca; Forbes-Hernandez, Tamara Y.; Calderón Iglesias, Rubén; Ruiz Salces, Roberto; Elexpuru Zabaleta, Maria; Cianciosi, Danila; Giampieri, Francesca y Battino, Maurizio mail francesca.pistollato@uneatlantico.es, SIN ESPECIFICAR, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2020) Pharmacological, non-pharmacological and stem cell therapies for the management of autism spectrum disorders: A focus on human studies. Pharmacological Research, 152. p. 104579. ISSN 1043-6618