TY  - JOUR
IS  - 1
SP  - 94
JF  - Cell
N2  - Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating heart. It is unclear whether these cells, which are long-lived and rarely renew, manage to preserve homeostasis on their own. While analyzing macrophages lodged within the healthy myocardium, we discovered that they actively took up material, including mitochondria, derived from cardiomyocytes. Cardiomyocytes ejected dysfunctional mitochondria and other cargo in dedicated membranous particles reminiscent of neural exophers, through a process driven by the cardiomyocyte?s autophagy machinery that was enhanced during cardiac stress. Depletion of cardiac macrophages or deficiency in the phagocytic receptor Mertk resulted in defective elimination of mitochondria from the myocardial tissue, activation of the inflammasome, impaired autophagy, accumulation of anomalous mitochondria in cardiomyocytes, metabolic alterations, and ventricular dysfunction. Thus, we identify an immune-parenchymal pair in the murine heart that enables transfer of unfit material to preserve metabolic stability and organ function.
Y1  - 2020/10//
UR  - http://doi.org/10.1016/j.cell.2020.08.031
SN  - 0092-8674
VL  - 183
ID  - uneatlantico124
EP  - 109.e23
TI  - A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
KW  - Macrophage; Mitochondria; Autophagy; Proteostasis; Phagocytosis; Heart.
AV  - none
A1  - Nicolás-Ávila, José A.
A1  - Lechuga-Vieco, Ana V.
A1  - Esteban-Martínez, Lorena
A1  - Sánchez-Díaz, María
A1  - Díaz-García, Elena
A1  - Santiago, Demetrio J.
A1  - Rubio-Ponce, Andrea
A1  - Li, Jackson LiangYao
A1  - Balachander, Akhila
A1  - Quintana, Juan A.
A1  - Martínez-de-Mena, Raquel
A1  - Castejón-Vega, Beatriz
A1  - Pun-García, Andrés
A1  - Través, Paqui G.
A1  - Bonzón-Kulichenko, Elena
A1  - García-Marqués, Fernando
A1  - Cussó, Lorena
A1  - A-González, Noelia
A1  - González-Guerra, Andrés
A1  - Roche-Molina, Marta
A1  - Martin-Salamanca, Sandra
A1  - Crainiciuc, Georgiana
A1  - Guzmán, Gabriela
A1  - Larrazabal, Jagoba
A1  - Herrero-Galán, Elías
A1  - Alegre-Cebollada, Jorge
A1  - Lemke, Greg
A1  - Rothlin, Carla V.
A1  - Jimenez-Borreguero, Luis Jesús
A1  - Reyes, Guillermo
A1  - Castrillo, Antonio
A1  - Desco, Manuel
A1  - Muñoz-Cánoves, Pura
A1  - Ibáñez, Borja
A1  - Torres, Miguel
A1  - Ng, Lai Guan
A1  - Priori, Silvia G.
A1  - Bueno, Héctor
A1  - Vázquez, Jesús
A1  - Cordero, Mario D.
A1  - Bernal, Juan A.
A1  - Enríquez, José A.
A1  - Hidalgo, Andrés
ER  -