<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart"^^ . "Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating heart. It is unclear whether these cells, which are long-lived and rarely renew, manage to preserve homeostasis on their own. While analyzing macrophages lodged within the healthy myocardium, we discovered that they actively took up material, including mitochondria, derived from cardiomyocytes. Cardiomyocytes ejected dysfunctional mitochondria and other cargo in dedicated membranous particles reminiscent of neural exophers, through a process driven by the cardiomyocyte’s autophagy machinery that was enhanced during cardiac stress. Depletion of cardiac macrophages or deficiency in the phagocytic receptor Mertk resulted in defective elimination of mitochondria from the myocardial tissue, activation of the inflammasome, impaired autophagy, accumulation of anomalous mitochondria in cardiomyocytes, metabolic alterations, and ventricular dysfunction. Thus, we identify an immune-parenchymal pair in the murine heart that enables transfer of unfit material to preserve metabolic stability and organ function."^^ . "2020-10" . . "183" . "1" . . "Cell"^^ . . . "00928674" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Lorena"^^ . "Cussó"^^ . "Lorena Cussó"^^ . . "Manuel"^^ . "Desco"^^ . "Manuel Desco"^^ . . "Noelia"^^ . "A-González"^^ . "Noelia A-González"^^ . . "Demetrio J."^^ . "Santiago"^^ . "Demetrio J. Santiago"^^ . . "Lai Guan"^^ . "Ng"^^ . "Lai Guan Ng"^^ . . "Guillermo"^^ . "Reyes"^^ . "Guillermo Reyes"^^ . . "Juan A."^^ . "Quintana"^^ . "Juan A. Quintana"^^ . . "Andrea"^^ . "Rubio-Ponce"^^ . "Andrea Rubio-Ponce"^^ . . "Mario D."^^ . "Cordero"^^ . "Mario D. Cordero"^^ . . "María"^^ . "Sánchez-Díaz"^^ . "María Sánchez-Díaz"^^ . . "Akhila"^^ . "Balachander"^^ . "Akhila Balachander"^^ . . "Raquel"^^ . "Martínez-de-Mena"^^ . "Raquel Martínez-de-Mena"^^ . . "Andrés"^^ . "González-Guerra"^^ . "Andrés González-Guerra"^^ . . "Greg"^^ . "Lemke"^^ . "Greg Lemke"^^ . . "Juan A."^^ . "Bernal"^^ . "Juan A. Bernal"^^ . . "Elías"^^ . "Herrero-Galán"^^ . "Elías Herrero-Galán"^^ . . "Jackson LiangYao"^^ . "Li"^^ . "Jackson LiangYao Li"^^ . . "Georgiana"^^ . "Crainiciuc"^^ . "Georgiana Crainiciuc"^^ . . "Andrés"^^ . "Hidalgo"^^ . "Andrés Hidalgo"^^ . . "Pura"^^ . "Muñoz-Cánoves"^^ . "Pura Muñoz-Cánoves"^^ . . "Miguel"^^ . "Torres"^^ . "Miguel Torres"^^ . . "Silvia G."^^ . "Priori"^^ . "Silvia G. Priori"^^ . . "Lorena"^^ . "Esteban-Martínez"^^ . "Lorena Esteban-Martínez"^^ . . "Paqui G."^^ . "Través"^^ . "Paqui G. Través"^^ . . "José A."^^ . "Nicolás-Ávila"^^ . "José A. Nicolás-Ávila"^^ . . "Andrés"^^ . "Pun-García"^^ . "Andrés Pun-García"^^ . . "José A."^^ . "Enríquez"^^ . "José A. Enríquez"^^ . . "Jagoba"^^ . "Larrazabal"^^ . "Jagoba Larrazabal"^^ . . "Jorge"^^ . "Alegre-Cebollada"^^ . "Jorge Alegre-Cebollada"^^ . . "Carla V."^^ . "Rothlin"^^ . "Carla V. Rothlin"^^ . . "Ana V."^^ . "Lechuga-Vieco"^^ . "Ana V. Lechuga-Vieco"^^ . . "Fernando"^^ . "García-Marqués"^^ . "Fernando García-Marqués"^^ . . "Beatriz"^^ . "Castejón-Vega"^^ . "Beatriz Castejón-Vega"^^ . . "Jesús"^^ . "Vázquez"^^ . "Jesús Vázquez"^^ . . "Borja"^^ . "Ibáñez"^^ . "Borja Ibáñez"^^ . . "Sandra"^^ . "Martin-Salamanca"^^ . "Sandra Martin-Salamanca"^^ . . "Antonio"^^ . "Castrillo"^^ . "Antonio Castrillo"^^ . . "Héctor"^^ . "Bueno"^^ . "Héctor Bueno"^^ . . "Luis Jesús"^^ . "Jimenez-Borreguero"^^ . "Luis Jesús Jimenez-Borreguero"^^ . . "Elena"^^ . "Díaz-García"^^ . "Elena Díaz-García"^^ . . "Elena"^^ . "Bonzón-Kulichenko"^^ . "Elena Bonzón-Kulichenko"^^ . . "Gabriela"^^ . "Guzmán"^^ . "Gabriela Guzmán"^^ . . "Marta"^^ . "Roche-Molina"^^ . "Marta Roche-Molina"^^ . . . . . "HTML Summary of #124 \n\nA Network of Macrophages Supports Mitochondrial Homeostasis in the Heart\n\n" . "text/html" . . . "Biomedicine"@en . "Biomedicina"@es . .