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primary topic: A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
type: AcademicArticle
type: Article
abstract: Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating heart. It is unclear whether these cells, which are long-lived and rarely renew, manage to preserve homeostasis on their own. While analyzing macrophages lodged within the healthy myocardium, we discovered that they actively took up material, including mitochondria, derived from cardiomyocytes. Cardiomyocytes ejected dysfunctional mitochondria and other cargo in dedicated membranous particles reminiscent of neural exophers, through a process driven by the cardiomyocyte’s autophagy machinery that was enhanced during cardiac stress. Depletion of cardiac macrophages or deficiency in the phagocytic receptor Mertk resulted in defective elimination of mitochondria from the myocardial tissue, activation of the inflammasome, impaired autophagy, accumulation of anomalous mitochondria in cardiomyocytes, metabolic alterations, and ventricular dysfunction. Thus, we identify an immune-parenchymal pair in the murine heart that enables transfer of unfit material to preserve metabolic stability and organ function.
date: 2020-10
volume: 183
issue: 1
is part of: Cell
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: Biomedicine

Cell
type: Collection
issn: 00928674

José A. Enríquez
type: Person
given name: José A.
family name: Enríquez

Jagoba Larrazabal
type: Person
given name: Jagoba
family name: Larrazabal

Lorena Esteban-Martínez
type: Person
given name: Lorena
family name: Esteban-Martínez

Silvia G. Priori
type: Person
given name: Silvia G.
family name: Priori

Guillermo Reyes
type: Person
given name: Guillermo
family name: Reyes

Manuel Desco
type: Person
given name: Manuel
family name: Desco

Paqui G. Través
type: Person
given name: Paqui G.
family name: Través

José A. Nicolás-Ávila
type: Person
given name: José A.
family name: Nicolás-Ávila

Elías Herrero-Galán
type: Person
given name: Elías
family name: Herrero-Galán

Pura Muñoz-Cánoves
type: Person
given name: Pura
family name: Muñoz-Cánoves

Juan A. Quintana
type: Person
given name: Juan A.
family name: Quintana

Andrea Rubio-Ponce
type: Person
given name: Andrea
family name: Rubio-Ponce

Jorge Alegre-Cebollada
type: Person
given name: Jorge
family name: Alegre-Cebollada

Raquel Martínez-de-Mena
type: Person
given name: Raquel
family name: Martínez-de-Mena

Juan A. Bernal
type: Person
given name: Juan A.
family name: Bernal

Lorena Cussó
type: Person
given name: Lorena
family name: Cussó

Miguel Torres
type: Person
given name: Miguel
family name: Torres

Sandra Martin-Salamanca
type: Person
given name: Sandra
family name: Martin-Salamanca

Gabriela Guzmán
type: Person
given name: Gabriela
family name: Guzmán

Borja Ibáñez
type: Person
given name: Borja
family name: Ibáñez

Fernando García-Marqués
type: Person
given name: Fernando
family name: García-Marqués

Jackson LiangYao Li
type: Person
given name: Jackson LiangYao
family name: Li

Luis Jesús Jimenez-Borreguero
type: Person
given name: Luis Jesús
family name: Jimenez-Borreguero

Andrés Hidalgo
type: Person
given name: Andrés
family name: Hidalgo

María Sánchez-Díaz
type: Person
given name: María
family name: Sánchez-Díaz

Jesús Vázquez
type: Person
given name: Jesús
family name: Vázquez

Elena Díaz-García
type: Person
given name: Elena
family name: Díaz-García

Elena Bonzón-Kulichenko
type: Person
given name: Elena
family name: Bonzón-Kulichenko

Noelia A-González
type: Person
given name: Noelia
family name: A-González

Antonio Castrillo
type: Person
given name: Antonio
family name: Castrillo

Akhila Balachander
type: Person
given name: Akhila
family name: Balachander

Marta Roche-Molina
type: Person
given name: Marta
family name: Roche-Molina

Héctor Bueno
type: Person
given name: Héctor
family name: Bueno

Beatriz Castejón-Vega
type: Person
given name: Beatriz
family name: Castejón-Vega

Andrés Pun-García
type: Person
given name: Andrés
family name: Pun-García

Demetrio J. Santiago
type: Person
given name: Demetrio J.
family name: Santiago

Georgiana Crainiciuc
type: Person
given name: Georgiana
family name: Crainiciuc

Andrés González-Guerra
type: Person
given name: Andrés
family name: González-Guerra

Ana V. Lechuga-Vieco
type: Person
given name: Ana V.
family name: Lechuga-Vieco

Carla V. Rothlin
type: Person
given name: Carla V.
family name: Rothlin

Greg Lemke
type: Person
given name: Greg
family name: Lemke

Lai Guan Ng
type: Person
given name: Lai Guan
family name: Ng

Mario D. Cordero
type: Person
given name: Mario D.
family name: Cordero

HTML Summary of #124 A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
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primary topic: A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Biomedicine
type: Concept
preferred label: Biomedicina @es