relation: http://repositorio.uneatlantico.es/id/eprint/124/ canonical: http://repositorio.uneatlantico.es/id/eprint/124/ title: A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart creator: Nicolás-Ávila, José A. creator: Lechuga-Vieco, Ana V. creator: Esteban-Martínez, Lorena creator: Sánchez-Díaz, María creator: Díaz-García, Elena creator: Santiago, Demetrio J. creator: Rubio-Ponce, Andrea creator: Li, Jackson LiangYao creator: Balachander, Akhila creator: Quintana, Juan A. creator: Martínez-de-Mena, Raquel creator: Castejón-Vega, Beatriz creator: Pun-García, Andrés creator: Través, Paqui G. creator: Bonzón-Kulichenko, Elena creator: García-Marqués, Fernando creator: Cussó, Lorena creator: A-González, Noelia creator: González-Guerra, Andrés creator: Roche-Molina, Marta creator: Martin-Salamanca, Sandra creator: Crainiciuc, Georgiana creator: Guzmán, Gabriela creator: Larrazabal, Jagoba creator: Herrero-Galán, Elías creator: Alegre-Cebollada, Jorge creator: Lemke, Greg creator: Rothlin, Carla V. creator: Jimenez-Borreguero, Luis Jesús creator: Reyes, Guillermo creator: Castrillo, Antonio creator: Desco, Manuel creator: Muñoz-Cánoves, Pura creator: Ibáñez, Borja creator: Torres, Miguel creator: Ng, Lai Guan creator: Priori, Silvia G. creator: Bueno, Héctor creator: Vázquez, Jesús creator: Cordero, Mario D. creator: Bernal, Juan A. creator: Enríquez, José A. creator: Hidalgo, Andrés subject: Biomedicina description: Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating heart. It is unclear whether these cells, which are long-lived and rarely renew, manage to preserve homeostasis on their own. While analyzing macrophages lodged within the healthy myocardium, we discovered that they actively took up material, including mitochondria, derived from cardiomyocytes. Cardiomyocytes ejected dysfunctional mitochondria and other cargo in dedicated membranous particles reminiscent of neural exophers, through a process driven by the cardiomyocyte’s autophagy machinery that was enhanced during cardiac stress. Depletion of cardiac macrophages or deficiency in the phagocytic receptor Mertk resulted in defective elimination of mitochondria from the myocardial tissue, activation of the inflammasome, impaired autophagy, accumulation of anomalous mitochondria in cardiomyocytes, metabolic alterations, and ventricular dysfunction. Thus, we identify an immune-parenchymal pair in the murine heart that enables transfer of unfit material to preserve metabolic stability and organ function. date: 2020-10 type: Artículo type: PeerReviewed identifier: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating heart. It is unclear whether these cells, which are long-lived and rarely renew, manage to preserve homeostasis on their own. While analyzing macrophages lodged within the healthy myocardium, we discovered that they actively took up material, including mitochondria, derived from cardiomyocytes. Cardiomyocytes ejected dysfunctional mitochondria and other cargo in dedicated membranous particles reminiscent of neural exophers, through a process driven by the cardiomyocyte’s autophagy machinery that was enhanced during cardiac stress. Depletion of cardiac macrophages or deficiency in the phagocytic receptor Mertk resulted in defective elimination of mitochondria from the myocardial tissue, activation of the inflammasome, impaired autophagy, accumulation of anomalous mitochondria in cardiomyocytes, metabolic alterations, and ventricular dysfunction. Thus, we identify an immune-parenchymal pair in the murine heart that enables transfer of unfit material to preserve metabolic stability and organ function. metadata Nicolás-Ávila, José A.; Lechuga-Vieco, Ana V.; Esteban-Martínez, Lorena; Sánchez-Díaz, María; Díaz-García, Elena; Santiago, Demetrio J.; Rubio-Ponce, Andrea; Li, Jackson LiangYao; Balachander, Akhila; Quintana, Juan A.; Martínez-de-Mena, Raquel; Castejón-Vega, Beatriz; Pun-García, Andrés; Través, Paqui G.; Bonzón-Kulichenko, Elena; García-Marqués, Fernando; Cussó, Lorena; A-González, Noelia; González-Guerra, Andrés; Roche-Molina, Marta; Martin-Salamanca, Sandra; Crainiciuc, Georgiana; Guzmán, Gabriela; Larrazabal, Jagoba; Herrero-Galán, Elías; Alegre-Cebollada, Jorge; Lemke, Greg; Rothlin, Carla V.; Jimenez-Borreguero, Luis Jesús; Reyes, Guillermo; Castrillo, Antonio; Desco, Manuel; Muñoz-Cánoves, Pura; Ibáñez, Borja; Torres, Miguel; Ng, Lai Guan; Priori, Silvia G.; Bueno, Héctor; Vázquez, Jesús; Cordero, Mario D.; Bernal, Juan A.; Enríquez, José A. y Hidalgo, Andrés mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, mario.cordero@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2020) A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart. Cell, 183 (1). 94-109.e23. ISSN 0092-8674 relation: http://doi.org/10.1016/j.cell.2020.08.031 relation: doi:10.1016/j.cell.2020.08.031 language: en