eprintid: 122 rev_number: 8 eprint_status: archive userid: 2 importid: 0 dir: disk0/00/00/01/22 datestamp: 2021-06-01 23:55:09 lastmod: 2022-03-03 23:55:08 status_changed: 2021-06-01 23:55:09 type: article succeeds: 0 commentary: 0 metadata_visibility: show item_issues_count: 0 sword_depositor: 0 creators_name: Anderson, Rozalyn creators_name: Cordero, Mario D. creators_name: Bullón, Pedro creators_name: Ruiz-Cabello, Jesús creators_name: Robertson, Avril A B creators_name: Ryffel, Bernhard creators_name: Pérez-Pulido, Antonio J creators_name: Muntané, Jordi creators_name: Pérez-Alegre, Mónica creators_name: Andújar-Pulido, Eloísa creators_name: de la Cruz, Patricia creators_name: Cooper, Matthew A creators_name: Lendines-Cordero, Debora creators_name: Alcocer-Gómez, Elísabet creators_name: Castejón-Vega, Beatriz creators_name: Marín-Aguilar, Fabiola creators_id: creators_id: mario.cordero@uneatlantico.es creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: title: NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica full_text_status: none keywords: NLRP3 inflammasome; Aging; Autophagy; MCC950; PPARα. abstract: The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related diseases in NLRP3-deficient mice. In this article, we determine whether, in old mice C57BL6J, the NLRP3 inflammasome inhibitor MCC950 is able to attenuate age-related metabolic syndrome to providing health benefits. We report that MCC950 attenuates metabolic and hepatic dysfunction in aged mice. In addition, MCC950 inhibited the Pi3K/AKT/mTOR pathway, enhanced autophagy, and activated peroxisome proliferator-activated receptor-α in vivo and in vitro. The data suggest that MCC950 mediates the protective effects by the mammalian target of rapamycin inhibition, thus activating autophagy and peroxisome proliferator-activated receptor-α. In conclusion, pharmacological inhibition of NLRP3 in aged mice has a significant impact on health. Thus, NLRP3 may be a therapeutic target of human age-related metabolic syndrome. date: 2019 date_type: published publication: The Journals of Gerontology: Series A volume: 75 number: 8 pagerange: 1457-1464 pages: 0 id_number: doi:10.1093/gerona/glz239 refereed: TRUE issn: 1079-5006 official_url: http://doi.org/10.1093/gerona/glz239 num_pieces: 0 gscholar_impact: 0 gscholar_datestamp: 0000-00-00 00:00:00 access: open language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related diseases in NLRP3-deficient mice. In this article, we determine whether, in old mice C57BL6J, the NLRP3 inflammasome inhibitor MCC950 is able to attenuate age-related metabolic syndrome to providing health benefits. We report that MCC950 attenuates metabolic and hepatic dysfunction in aged mice. In addition, MCC950 inhibited the Pi3K/AKT/mTOR pathway, enhanced autophagy, and activated peroxisome proliferator-activated receptor-α in vivo and in vitro. The data suggest that MCC950 mediates the protective effects by the mammalian target of rapamycin inhibition, thus activating autophagy and peroxisome proliferator-activated receptor-α. In conclusion, pharmacological inhibition of NLRP3 in aged mice has a significant impact on health. Thus, NLRP3 may be a therapeutic target of human age-related metabolic syndrome. metadata Anderson, Rozalyn; Cordero, Mario D.; Bullón, Pedro; Ruiz-Cabello, Jesús; Robertson, Avril A B; Ryffel, Bernhard; Pérez-Pulido, Antonio J; Muntané, Jordi; Pérez-Alegre, Mónica; Andújar-Pulido, Eloísa; de la Cruz, Patricia; Cooper, Matthew A; Lendines-Cordero, Debora; Alcocer-Gómez, Elísabet; Castejón-Vega, Beatriz y Marín-Aguilar, Fabiola mail SIN ESPECIFICAR, mario.cordero@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2019) NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity. The Journals of Gerontology: Series A, 75 (8). pp. 1457-1464. ISSN 1079-5006