<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity"^^ . "The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related diseases in NLRP3-deficient mice. In this article, we determine whether, in old mice C57BL6J, the NLRP3 inflammasome inhibitor MCC950 is able to attenuate age-related metabolic syndrome to providing health benefits. We report that MCC950 attenuates metabolic and hepatic dysfunction in aged mice. In addition, MCC950 inhibited the Pi3K/AKT/mTOR pathway, enhanced autophagy, and activated peroxisome proliferator-activated receptor-α in vivo and in vitro. The data suggest that MCC950 mediates the protective effects by the mammalian target of rapamycin inhibition, thus activating autophagy and peroxisome proliferator-activated receptor-α. In conclusion, pharmacological inhibition of NLRP3 in aged mice has a significant impact on health. Thus, NLRP3 may be a therapeutic target of human age-related metabolic syndrome."^^ . "2019" . . "75" . "8" . . "The Journals of Gerontology: Series A"^^ . . . "10795006" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Mario D."^^ . "Cordero"^^ . "Mario D. Cordero"^^ . . "Eloísa"^^ . "Andújar-Pulido"^^ . "Eloísa Andújar-Pulido"^^ . . "Patricia"^^ . "de la Cruz"^^ . "Patricia de la Cruz"^^ . . "Beatriz"^^ . "Castejón-Vega"^^ . "Beatriz Castejón-Vega"^^ . . "Mónica"^^ . "Pérez-Alegre"^^ . "Mónica Pérez-Alegre"^^ . . "Antonio J"^^ . "Pérez-Pulido"^^ . "Antonio J Pérez-Pulido"^^ . . "Matthew A"^^ . "Cooper"^^ . "Matthew A Cooper"^^ . . "Debora"^^ . "Lendines-Cordero"^^ . "Debora Lendines-Cordero"^^ . . "Rozalyn"^^ . "Anderson"^^ . "Rozalyn Anderson"^^ . . "Bernhard"^^ . "Ryffel"^^ . "Bernhard Ryffel"^^ . . "Jesús"^^ . "Ruiz-Cabello"^^ . "Jesús Ruiz-Cabello"^^ . . "Elísabet"^^ . "Alcocer-Gómez"^^ . "Elísabet Alcocer-Gómez"^^ . . "Pedro"^^ . "Bullón"^^ . "Pedro Bullón"^^ . . "Fabiola"^^ . "Marín-Aguilar"^^ . "Fabiola Marín-Aguilar"^^ . . "Avril A B"^^ . "Robertson"^^ . "Avril A B Robertson"^^ . . "Jordi"^^ . "Muntané"^^ . "Jordi Muntané"^^ . . . . . "HTML Summary of #122 \n\nNLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity\n\n" . "text/html" . . . "Biomedicine"@en . "Biomedicina"@es . .