relation: http://repositorio.uneatlantico.es/id/eprint/122/ canonical: http://repositorio.uneatlantico.es/id/eprint/122/ title: NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity creator: Anderson, Rozalyn creator: Cordero, Mario D. creator: Bullón, Pedro creator: Ruiz-Cabello, Jesús creator: Robertson, Avril A B creator: Ryffel, Bernhard creator: Pérez-Pulido, Antonio J creator: Muntané, Jordi creator: Pérez-Alegre, Mónica creator: Andújar-Pulido, Eloísa creator: de la Cruz, Patricia creator: Cooper, Matthew A creator: Lendines-Cordero, Debora creator: Alcocer-Gómez, Elísabet creator: Castejón-Vega, Beatriz creator: Marín-Aguilar, Fabiola subject: Biomedicina description: The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related diseases in NLRP3-deficient mice. In this article, we determine whether, in old mice C57BL6J, the NLRP3 inflammasome inhibitor MCC950 is able to attenuate age-related metabolic syndrome to providing health benefits. We report that MCC950 attenuates metabolic and hepatic dysfunction in aged mice. In addition, MCC950 inhibited the Pi3K/AKT/mTOR pathway, enhanced autophagy, and activated peroxisome proliferator-activated receptor-α in vivo and in vitro. The data suggest that MCC950 mediates the protective effects by the mammalian target of rapamycin inhibition, thus activating autophagy and peroxisome proliferator-activated receptor-α. In conclusion, pharmacological inhibition of NLRP3 in aged mice has a significant impact on health. Thus, NLRP3 may be a therapeutic target of human age-related metabolic syndrome. date: 2019 type: Artículo type: PeerReviewed identifier: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related diseases in NLRP3-deficient mice. In this article, we determine whether, in old mice C57BL6J, the NLRP3 inflammasome inhibitor MCC950 is able to attenuate age-related metabolic syndrome to providing health benefits. We report that MCC950 attenuates metabolic and hepatic dysfunction in aged mice. In addition, MCC950 inhibited the Pi3K/AKT/mTOR pathway, enhanced autophagy, and activated peroxisome proliferator-activated receptor-α in vivo and in vitro. The data suggest that MCC950 mediates the protective effects by the mammalian target of rapamycin inhibition, thus activating autophagy and peroxisome proliferator-activated receptor-α. In conclusion, pharmacological inhibition of NLRP3 in aged mice has a significant impact on health. Thus, NLRP3 may be a therapeutic target of human age-related metabolic syndrome. metadata Anderson, Rozalyn; Cordero, Mario D.; Bullón, Pedro; Ruiz-Cabello, Jesús; Robertson, Avril A B; Ryffel, Bernhard; Pérez-Pulido, Antonio J; Muntané, Jordi; Pérez-Alegre, Mónica; Andújar-Pulido, Eloísa; de la Cruz, Patricia; Cooper, Matthew A; Lendines-Cordero, Debora; Alcocer-Gómez, Elísabet; Castejón-Vega, Beatriz y Marín-Aguilar, Fabiola mail SIN ESPECIFICAR, mario.cordero@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2019) NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity. The Journals of Gerontology: Series A, 75 (8). pp. 1457-1464. ISSN 1079-5006 relation: http://doi.org/10.1093/gerona/glz239 relation: doi:10.1093/gerona/glz239 language: en