<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Sequential Changes of NLRP3 Inflammasome Activation in Sepsis and its Relationship With Death"^^ . "Introduction: \nInflammasomes are recognized as key components of the innate immune response in sepsis. We aimed to describe the transcriptional expression of nucleotide-binding domain, leucine-rich repeat–containing receptor, pyrin domain–containing-3 (NLRP3), and serum interleukin-1β (IL-1 β) in critically ill patients, their changes over the first week and their prognostic value in septic patients.\n\nMethods: \nProspective study including patients with sepsis based on Sepsis-3 definitions and a control group of critically ill patients without sepsis. We measured the circulating levels of IL-1β as well as the transcriptional expression of NLRP3 at admission and on days 3 and 7. Caspase-1 and caspase-3 activation was analyzed in a matched cohort of patients with septic shock (four dead and four survivors).\n\nResults: \nFifty-five septic patients and 11 non-septic patients were studied. Levels on day 0 and 3 of IL-1 β and NLRP3 inflammasome expression were significantly higher in patients with sepsis than in controls. NLRP3 was significantly higher in septic patients who survived at day 7 without significant difference between survivors and non-survivors at baseline and on day 3. In survivors, an increased caspase-1 protein expression with reduced expression caspase-3 was observed with the opposite pattern in those who died.\n\nConclusions: \nNLRP3 is activated in critically ill patients but this up-regulation is more intense in patients with sepsis. In sepsis, a sustained NLRP3 activation during the first week is protective and sepsis. An increased caspase-1 protein expression with reduced expression caspase-3 is the pattern observed in septic shock patients who survive."^^ . "2020-09" . . "54" . "3" . . "Shock"^^ . . . "10732322" . . . . . . . . . . . . . . . . . . . . . . . . . "Mario D."^^ . "Cordero"^^ . "Mario D. Cordero"^^ . . "Ana"^^ . "Díaz-Martín"^^ . "Ana Díaz-Martín"^^ . . "Elísabet Alcocer"^^ . "Gómez"^^ . "Elísabet Alcocer Gómez"^^ . . "Inmaculada"^^ . "Palacios-García"^^ . "Inmaculada Palacios-García"^^ . . "José M."^^ . "López-Sánchez"^^ . "José M. López-Sánchez"^^ . . "Antonio"^^ . "Gutiérrez-Pizarraya"^^ . "Antonio Gutiérrez-Pizarraya"^^ . . "José"^^ . "Garnacho-Montero"^^ . "José Garnacho-Montero"^^ . . . . . "HTML Summary of #119 \n\nSequential Changes of NLRP3 Inflammasome Activation in Sepsis and its Relationship With Death\n\n" . "text/html" . . . "Biomedicine"@en . "Biomedicina"@es . .