@article{uneatlantico119,
            year = {2020},
         journal = {Shock},
           title = {Sequential Changes of NLRP3 Inflammasome Activation in Sepsis and its Relationship With Death},
          number = {3},
           month = {Septiembre},
          author = {Jos{\'e} Garnacho-Montero and Inmaculada Palacios-Garc{\'i}a and Ana D{\'i}az-Mart{\'i}n and Antonio Guti{\'e}rrez-Pizarraya and Jos{\'e} M. L{\'o}pez-S{\'a}nchez and El{\'i}sabet Alcocer G{\'o}mez and Mario D. Cordero},
          volume = {54},
           pages = {294--300},
        keywords = {Caspase-1;  Caspase-3;  inflammation ; Mortality; NLRP3 inflammasome NLRP3 inflammasome;  Sepsis.},
        abstract = {Introduction: 
Inflammasomes are recognized as key components of the innate immune response in sepsis. We aimed to describe the transcriptional expression of nucleotide-binding domain, leucine-rich repeat?containing receptor, pyrin domain?containing-3 (NLRP3), and serum interleukin-1{\ensuremath{\beta}} (IL-1 {\ensuremath{\beta}}) in critically ill patients, their changes over the first week and their prognostic value in septic patients.

Methods: 
Prospective study including patients with sepsis based on Sepsis-3 definitions and a control group of critically ill patients without sepsis. We measured the circulating levels of IL-1{\ensuremath{\beta}} as well as the transcriptional expression of NLRP3 at admission and on days 3 and 7. Caspase-1 and caspase-3 activation was analyzed in a matched cohort of patients with septic shock (four dead and four survivors).

Results: 
Fifty-five septic patients and 11 non-septic patients were studied. Levels on day 0 and 3 of IL-1 {\ensuremath{\beta}} and NLRP3 inflammasome expression were significantly higher in patients with sepsis than in controls. NLRP3 was significantly higher in septic patients who survived at day 7 without significant difference between survivors and non-survivors at baseline and on day 3. In survivors, an increased caspase-1 protein expression with reduced expression caspase-3 was observed with the opposite pattern in those who died.

Conclusions: 
NLRP3 is activated in critically ill patients but this up-regulation is more intense in patients with sepsis. In sepsis, a sustained NLRP3 activation during the first week is protective and sepsis. An increased caspase-1 protein expression with reduced expression caspase-3 is the pattern observed in septic shock patients who survive.},
             url = {http://repositorio.uneatlantico.es/id/eprint/119/}
}