eprintid: 117 rev_number: 10 eprint_status: archive userid: 2 importid: 0 dir: disk0/00/00/01/17 datestamp: 2021-06-01 23:55:08 lastmod: 2021-07-08 23:55:12 status_changed: 2021-06-01 23:55:08 type: article succeeds: 0 commentary: 0 metadata_visibility: show item_issues_count: 0 sword_depositor: 0 creators_name: Varela-López, Alfonso creators_name: Bullón, Pedro creators_name: Ramírez-Tortosa, César L. creators_name: Navarro-Hortal, María D. creators_name: Robles-Almazán, María creators_name: Bullón, Beatriz creators_name: Cordero, Mario D. creators_name: Battino, Maurizio creators_name: Quiles, José L. creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: mario.cordero@uneatlantico.es creators_id: creators_id: title: A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: Atherogenic; Atherosclerosis; NASH; Non-alcoholic fatty liver disease; Periodontal diseases; Periodontitis; Rabbits. abstract: ncreasing evidence connects periodontitis with a variety of systemic diseases, including metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD progression to non-alcoholic steatohepatitis. Male rabbits were maintained on a commercial standard diet or a diet rich in saturated fat (3% lard w/w) and cholesterol (1.3% w/w) (HFD) for 40 days. Half of the rabbits on each diet were treated 2 days per week with intragingival injections of LPS from Porphyromonas gingivalis. Morphometric analyses revealed that LPS induced higher alveolar bone loss (ABL) around the first premolar in animals receiving standard diets, which was exacerbated by the HFD diet. A higher score of acinar inflammation in the liver and higher blood levels of triglycerides and phospholipids were found in HFD-fed rabbits receiving LPS. These results suggest that certain dietary habits can exacerbate some aspects of periodontitis and that bad periodontal health can contribute to dyslipidemia and promote NAFLD progression, but only under certain conditions. date: 2020 date_type: published publication: Nutrients volume: 12 number: 5 pagerange: 1405 pages: 0 id_number: doi:10.3390/nu12051405 refereed: TRUE issn: 2072-6643 official_url: http://doi.org/10.3390/nu12051405 num_pieces: 0 gscholar_impact: 0 gscholar_datestamp: 0000-00-00 00:00:00 citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica SIN ESPECIFICAR SIN ESPECIFICAR ncreasing evidence connects periodontitis with a variety of systemic diseases, including metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD progression to non-alcoholic steatohepatitis. Male rabbits were maintained on a commercial standard diet or a diet rich in saturated fat (3% lard w/w) and cholesterol (1.3% w/w) (HFD) for 40 days. Half of the rabbits on each diet were treated 2 days per week with intragingival injections of LPS from Porphyromonas gingivalis. Morphometric analyses revealed that LPS induced higher alveolar bone loss (ABL) around the first premolar in animals receiving standard diets, which was exacerbated by the HFD diet. A higher score of acinar inflammation in the liver and higher blood levels of triglycerides and phospholipids were found in HFD-fed rabbits receiving LPS. These results suggest that certain dietary habits can exacerbate some aspects of periodontitis and that bad periodontal health can contribute to dyslipidemia and promote NAFLD progression, but only under certain conditions. metadata Varela-López, Alfonso; Bullón, Pedro; Ramírez-Tortosa, César L.; Navarro-Hortal, María D.; Robles-Almazán, María; Bullón, Beatriz; Cordero, Mario D.; Battino, Maurizio y Quiles, José L. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, mario.cordero@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2020) A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease. Nutrients, 12 (5). p. 1405. ISSN 2072-6643 document_url: http://repositorio.uneatlantico.es/id/eprint/117/1/nutrients-12-01405.pdf